1075188-98-5

Basic information

• Product Name: N-(4-bromo-3-methylphenyl)-7-chlorobenzo[d]oxazol-2-amine
• CAS NO: 1075188-98-5
• Molecular Weight: 337.603
• Mol File: 1075188-98-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-bromo-3-methylphenyl)-7-chlorobenzo[d]oxazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromo-3-methylphenyl)-7-chlorobenzo[d]oxazol-2-amine(1075188-98-5)
• EPA Substance Registry System: N-(4-bromo-3-methylphenyl)-7-chlorobenzo[d]oxazol-2-amine(1075188-98-5)

Safety Data

• Hazardous Substances Data: 1075188-98-5(Hazardous Substances Data)

Upstream product

• 71672-88-3 4-bromo-3-methylbenzeneisothiocyanate 
• 38191-33-2 2-amino-6-chlorophenol 

Downstream Products

• 1075188-99-6 7-chloro-N-(3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzo[d]oxazol-2-amine 

Relevant articles and documents

Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases

This Letter describes the lead discovery, optimization, and biological characterization of a series of substituted 4-amino-1H-pyrazolo[3,4-d] pyrimidines as potent inhibitors of IGF1R, EGFR, and ErbB2. The leading compound 11 showed an IGF1R IC50 of 12 nM, an EGFR (L858R) IC50 of 31 nM, and an ErbB2 IC50 of 11 nM, potent activity in cellular functional and anti-proliferation assays, as well as activity in an in vivo pharmacodynamic assay.