1075230-69-1Relevant articles and documents
Trifluoromethyl Dihydrothiazine-Based β-Secretase (BACE1) Inhibitors with Robust Central β-Amyloid Reduction and Minimal Covalent Binding Burden
Anan, Kosuke,Iso, Yasuyoshi,Oguma, Takuya,Nakahara, Kenji,Suzuki, Shinji,Yamamoto, Takahiko,Matsuoka, Eriko,Ito, Hisanori,Sakaguchi, Gaku,Ando, Shigeru,Morimoto, Kenji,Kanegawa, Naoki,Kido, Yasuto,Kawachi, Tomoyuki,Fukushima, Tamio,Teisman, Ard,Urmaliya, Vijay,Dhuyvetter, Deborah,Borghys, Herman,Austin, Nigel,Van Den Bergh, An,Verboven, Peter,Bischoff, Francois,Gijsen, Harrie J. M.,Yamano, Yoshinori,Kusakabe, Kenichi
, p. 1894 - 1910 (2019/11/22)
The β-site amyloid precursor protein cleaving enzyme 1 (BACE1, also known as β-secretase) is a promising target for the treatment of Alzheimer's disease. A pKa lowering approach over the initial leads was adopted to mitigate hERG inhibition and
AMINODIHYDROTHIAZINE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUPS
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Page/Page column 35, (2010/02/17)
This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alk
PHARMACEUTICAL COMPOSITION FOR TREATMENT OF ALZHEIMER'S DISEASE
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Page/Page column 72, (2010/03/02)
A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene,