107599-40-6

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 1-ethylpyrrolidine-2-carboxylate is used as a synthetic intermediate for the development of pharmaceutical compounds. Its unique structure and reactivity allow it to be incorporated into the synthesis of complex organic molecules, contributing to the creation of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, Methyl 1-ethylpyrrolidine-2-carboxylate is utilized as a building block for the synthesis of various agrochemicals. Its properties enable it to be a part of the development process for new pesticides, herbicides, and other agricultural chemicals, enhancing crop protection and yield.
Used in Chemical Industry:
Methyl 1-ethylpyrrolidine-2-carboxylate is employed as a versatile intermediate in the chemical industry for the synthesis of a wide range of organic molecules. Its structural and reactive features make it a valuable component in the production of specialty chemicals, fine chemicals, and other advanced materials.

InChI:InChI=1/C8H15NO2/c1-3-9-6-4-5-7(9)8(10)11-2/h7H,3-6H2,1-2H3

Upstream product

• 2133-40-6 L-proline methyl ester monohydrochloride 
• 75-07-0 acetaldehyde 
• 147-85-3 L-proline 
• 533-88-0 2-amino-5-hydroxyvaleric acid 
• 7335-06-0 1-ethylpyrrolidine 
• 616-38-6 carbonic acid dimethyl ester 
• 27460-51-1 N-acetyl-proline methyl ester 
• 74-96-4 ethyl bromide 
• 2133-40-6 methyl pyrrolidine-2-carboxylate hydrochloride 
• 62-50-0 Ethyl methanesulfonate 

Downstream Products

• 98435-76-8 (S)-1-ethyl-pyrrolidine-2-carboxylic acid 
• 73058-14-7 methyl 1-ethyl-1H-pyrrole-2-carboxylate 

Relevant academic research and scientific papers

Preparation method of (s)-N-ethyl-2-aminomethylpyrrolidine

The invention provides a preparation method of (s)-N-ethyl-2-aminomethylpyrrolidine. 2-amino-5-hydroxyvaleric acid used as a raw material undergoes esterification protection to obtain methyl 2-amino-5-hydroxypentanoate, N-ethylation is further achieved through bromoethane, and then the N-ethyl-2-aminomethylpyrrolidine is prepared through hydroxyl halogenation, substitution cyclization, ammonolysisand reduction six-step reaction. High-cost raw materials and an N,O-diethylation reaction are successfully avoided, and the method has the advantages of easiness in implementation of the above reaction route, few byproducts, high yield reaching 64.2%, and suitableness for industrialization.

EPHA4 CYCLIC PEPTIDE ANTAGONISTS AND METHODS OF USE THEREOF

Disclosed herein are compounds and methods of use thereof for the modulation of EphA4 receptor activity. In an aspect, is provided a method of treating or preventing a disease or disorder mediated by EphA4, comprising administering to a subject in need thereof a therapeutically effective amount of a compound as described herein, including certain embodiments, or the structural Formula (I), (l-A), (II), (III), (IV), (IV-1), (V), (Vl-A), (Vl-B), (VII-1), (VII-2), (VIII-1), or (VIII-2), or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, or hydrate thereof.

Synthesis of Lepadiformine Using a Hydroamination Transform

Dissection of lepadiformine by a double hydroamination transform affords a simple achiral amino diene. This reaction is accomplished in the forward sense by amine-directed hydroboration and an oxidative alkyl shift to nitrogen, both of which occur with hi

Selective reduction of amides to amines by boronic acid catalyzed hydrosilylation

Not a 'B'ore! Benzothiophene-based boronic acids catalyze the reduction of tertiary, secondary, and primary amides in the presence of a hydrosilane. The reaction demonstrates good functional-group tolerance. Copyright

SUBSTITUTED BENZAMIDE MODULATORS OF DOPAMINE RECEPTOR

The present invention relates to new substituted benzamide modulators of dopamine receptor, pharmaceutical compositions thereof, and methods of use thereof.

EFFICIENT STEREOCONSERVATIVE SYNTHESIS OF 1-SUBSTITUTED (S)- AND (R)-2-AMINOMETHYLPYRROLIDINES AND INTERMEDIATES THERETO

Stereoconservative method for preparation of an (R)- or (S)-isomer of the compound of the formula I with at least 95% optical purity wherein R1 is a hydrogen atom, a saturated or unsaturated lower alkyl group, a cycloalkyl group, or a group (CH2)m Ph wherein m is 0-3 and Ph is a substituted or unsubstituted phenyl group including 1) O,N-dialkylation, directly or stepwise of (R)- or (S)-proline 2) aminolysis 3) reduction to formation of the (R)- or (S)-isomer of the compound of the formula I, and new intermediates II and III in optical active form obtained by the reaction steps above and wherein R2 is defined as R1 above.