1076189-60-0

Basic information

• Product Name: methyl (2S,4R)-4-((methylsulfonyl)oxy)-1-(p-tolylsulfonyl)pyrrolidine-2-carboxylate
• Synonyms: methyl (2S,4R)-4-((methylsulfonyl)oxy)-1-(p-tolylsulfonyl)pyrrolidine-2-carboxylate
• CAS NO: 1076189-60-0
• Molecular Weight: 377.439
• Mol File: 1076189-60-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl (2S,4R)-4-((methylsulfonyl)oxy)-1-(p-tolylsulfonyl)pyrrolidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2S,4R)-4-((methylsulfonyl)oxy)-1-(p-tolylsulfonyl)pyrrolidine-2-carboxylate(1076189-60-0)
• EPA Substance Registry System: methyl (2S,4R)-4-((methylsulfonyl)oxy)-1-(p-tolylsulfonyl)pyrrolidine-2-carboxylate(1076189-60-0)

Safety Data

• Hazardous Substances Data: 1076189-60-0(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 51-35-4 4R-4-hydroxyproline 
• 16257-57-1 methyl (2S,4R)-4-hydroxy-1-(p-tolylsulfonyl)pyrrolidine-2-carboxylate 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 81519-89-3 methyl (2S,4S)-4-amino-1-(p-tolylsulfonyl)pyrrolidine-2-carboxylate 
• 20275-13-2 methyl (2S,4S)-4-azido-1-(p-tolylsulfonyl)pyrrolidine-2-carboxylate 

Relevant articles and documents

Diastereoselective Diboration of Cyclic Alkenes: Application to the Synthesis of Aristeromycin

The Pt-catalyzed diboration of cyclic alkenes is extended to unsaturated heterocycles and bicyclic compounds and can be accomplished in a diastereoselective fashion. The optimal procedures, substrate scope, and diastereoselectivity were investigated, and examples employing both homogeneous and heterogeneous catalysis were examined. Lastly, application to the construction of the nucleoside analog (±)-aristeromycin was conducted.

Synthesis of new sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors

A series of new sulfonyl pyrrolidine derivatives was designed, synthesized, and assayed for their inhibitory activities on matrix metalloproteinase 2 (MMP-2) and aminopeptidase N (AP-N). The results showed that these pyrrolidine derivatives exhibited highly selective inhibition against MMP-2 as compared with AP-N. The compounds 4c, 4j, 5a, and 5b were equally or more potent MMP-2 inhibitors than the positive control LY52. The FlexX docking was done to explain the reason for the different potency between MMP-2 and AP-N. Structure-activity relationships were also briefly discussed.