107686-44-2

Upstream product

• 354-58-5 1,1,1-Trichloro-2,2,2-trifluoroethane 
• 108-24-7 acetic anhydride 
• 100-52-7 benzaldehyde 
• 103654-96-2 1-(α,α-dichloro-β,β,β-trifluoroethyl)benzylalcohol 

Downstream Products

• 34091-69-5 (2-chloro-3,3,3-trifluoroprop-1-en-1-yl)benzene 
• 34091-69-5 [(1E)-2-chloro-3,3,3-trifluoro-1-propenyl]benzene 
• 34093-70-4 (Z)-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)benzene 

Relevant academic research and scientific papers

THE SYNTHESIS OF OPTICALLY ACTIVE BUILDING BLOCKS CARRYING AN α,α-DIHALOGENO-β,β,β-TRIFLUOROETHYL GROUP

Optically active molecules with α,α-dihalogeno-β,β,β-trifluoroethyl groups were prepared by the microbial hydrolysis of the corresponding esters.

Efficient Carbonyl Addition of Polyfluorochloroethyl, -ethylidene, and -ethenyl Units by Means of 1,1,1-Trichloro-2,2,2-trifluoroethane and Zinc

Thermally stable zinc carbenoid CF3CCl2ZnCl was prepared from 1,1,1-trichloro-2,2,2-trifluoroethane and zinc powder in N,N-dimethylformamide and was allowed to add to carbonyls of aldehydes and α-keto esters in excellent yields to give 1-substituted 2,2-d

PRACTICAL AND STEREOCONTROLLED SYNTHESES OF BOTH (1R*,3S*)- AND (1R*,3R*)-3-(2-CHLORO-3,3,3-TRIFLUORO-1-PROPENYL)-2,2-DIMETHYLCYCLOPROPANECARBOXYLATES

The title compounds of (1R*,3S*) configuration were prepared from 3-formyl-2,2-dimethylcyclopropanecarboxylate by addition of CF3CCl2ZnCl, acetylation, and reductive β-elimination with zinc, whereas the (1R*,3R*) isomer was derived from Me2C=CHCH(OH)CCl2CF3 by diazoacetylation, Cu(II) catalyzed intramolecular cyclization, and the zinc reduction.