103654-96-2

Basic information

• Product Name: Benzenemethanol, a-(1,1-dichloro-2,2,2-trifluoroethyl)-
• CAS NO: 103654-96-2
• Molecular Formula: C9H7Cl2F3O
• Molecular Weight: 259.055
• Mol File: 103654-96-2.mol

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-(1,1-dichloro-2,2,2-trifluoroethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-(1,1-dichloro-2,2,2-trifluoroethyl)-(103654-96-2)
• EPA Substance Registry System: Benzenemethanol, a-(1,1-dichloro-2,2,2-trifluoroethyl)-(103654-96-2)

Safety Data

• Hazardous Substances Data: 103654-96-2(Hazardous Substances Data)

Upstream product

• 306-83-2 1,1,1-trifluoro-2,2-dichloroethane 
• 100-52-7 benzaldehyde 
• 354-58-5 1,1,1-Trichloro-2,2,2-trifluoroethane 
• 2043-61-0 cyclohexanecarbaldehyde 
• 13710-18-4 C₂Cl₃F₃Zn 

Downstream Products

• 1579-80-2 (3,3,3-trifluoropropyl)benzene 
• 709-21-7 3,3,3-trifluoro-1-phenylpropan-1-one 
• 705-89-5 (E)-3,3,3-trifluoro-1-phenylpropene 
• 2340-22-9 methyl phenyl(3,3,3-trifluoro-1-phenylpropoxy)carbamate 
• 155270-04-5 2,2-dichloro-3,3,3-trifluoropropiophenone 
• 122247-06-7 3-(2,6-Dichloro-phenyl)-5-(4-nitro-phenyl)-4-trifluoromethyl-isoxazole 
• 122247-13-6 3-(2,6-Dichloro-phenyl)-4-(4-nitro-phenyl)-5-trifluoromethyl-isoxazole 
• 1983-22-8 1-nitro-4-(3,3,3-trifluoroprop-1-yn-1-yl)benzene 
• 94837-99-7 1-[2-chloro-3,3,3-trifluoro-1-propenyl]-4-nitrobenzene 
• 34093-70-4 (Z)-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)benzene 
• 34091-69-5 [(1E)-2-chloro-3,3,3-trifluoro-1-propenyl]benzene 
• 119342-91-5 (1-Allyloxy-2,2-dichloro-3,3,3-trifluoro-propyl)-benzene 
• 107686-45-3 2,2-dichloro-3,3,3-trifluoro-1-phenylpropyl methanesulfonate 
• 107686-44-2 2,2-dichloro-3,3,3-trifluoro-1-phenyl-1-propyl acetate 

Relevant articles and documents

Fluorine-Containing Organozinc Reagents. Part I. A Simple Synthesis of 2,2-Dichloro-3,3,3-trifluoropropanol

The title compound 1, which can be regarded as synthetic equivalent of substituted 1,1,1-trifluoroacetone 2, is prepared by Zn-induced reductive addition of 1,1,1-trichloro-2,2,2-trifluoroethane (3) to formaldehyde (4).A brief survey of the scope of this C-C-bond formation leading to a variety of new CF3-containing synthetic building blocks is also given.

THE SYNTHESIS OF OPTICALLY ACTIVE BUILDING BLOCKS CARRYING AN α,α-DIHALOGENO-β,β,β-TRIFLUOROETHYL GROUP

Optically active molecules with α,α-dihalogeno-β,β,β-trifluoroethyl groups were prepared by the microbial hydrolysis of the corresponding esters.

Direct electroreduction or use of an electrogenerated base : Two ways for the coupling of polyhalogenated compounds with aldehydes or ketones

The electrochemical coupling of polyhalogenated compounds with carbonyl compounds is achieved in two ways. A carbanion RX(n)- is generated either by the direct electroreduction of RX(n)Cl or by deprotonation of RX(n)H. In this latter case the base Ph- is electrogenerated by reduction of iodobenzene. All electrolysis were carried out in an undivided cell fitted with a cadmium-coated cathode and an aluminium or magnesium sacrificial anode.

Synthetic utility of HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane): the reaction between HCFC-123 and aldehydes using zinc

HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) reacted with zinc and aldehydes to afford predominantly either 1-substituted 2-chloro-3,3-difluoro-2-propen-1-ols or 1-substituted 2,2-dichloro-3,3,3-trifluoro-1-propanols.The reactions proceeded via 1,1-dichloro-2,2,2-trifluoroethylzinc chloride as an organozinc intermediate. - Keywords: 2,2-Dichloro-1,1,1-trifluoroethane; Reaction; Aldehydes; Zinc; 1,1-Dichloro-2,2,2-trifluoroethylzinc chloride

Electroorganic Chemistry. 130. A Novel Trifluoromethylation of Aldehydes and Ketones Promoted by an Electrogenerated Base

A base generated by the electroreduction of 2-pyrrolidone deprotonated trifluoromethane to form a trifluoromethyl anion equivalent.In the presence of hexamethyldisilazane, this species reacted with a variety of aldehydes and ketones to afford (trifluoromethyl)-carbinols in high yield.

Electroreductive coupling of halofluoro compounds with aldehydes

Electroreductive intermolecular coupling of halofluoro compounds such as 1,1,1-trichloro-2,2,2-trifluoroethane, methyl chlorodifluoroacetate, and perfluoroalkyl halides with aldehydes took place effectively in the presence of chlorotrimethylsilane and one of the coupling products, 2,2-dichloro-3,3,3-trifluoro-1-phenyl-1-propranol, was selectively convertible to a variety of compounds with using the electroreduction as a key reaction.

1,1-DICHLORO-2,2,2-TRIFLUOROETHYL ZINC AND LITHIUM COMPOUNDS IN ASYMMETRIC SYNTHESIS

Addition of 1,1-dichloro-2,2,2-trifluoroethyl zinc chloride 2 complexed with optically pure ligands leads to zero percentage of asymmetric induction due to too large a distance between the chiral centers involved.However, addition of 2 and of the correspo

A Facile Stereoselcetive Synthesis of (E)-1-Aryl-1,2,3,3,3-pentafluoropropenes and (E)-1-Aryl-2-chloro-1,3,3,3-tetrafluoropropenes

Arenecarbaldehydes ArCHO were allowed to react with a carbenoid reagent CF3CX2Mtl (X=Cl, Mtl=ZnCl, X=F, Mtl=LI) to give the adducts ArCH(OH)CX2CF3 whose hydroxyl group was substituted by fluorine.Dehydrohalogenating of the resultant ArCHFCX2CF3 (X=Cl or F

Radical Cyclization of Trifluoromethyl-substituted Carbon: A Facile Preparation of Trifluoromethylated Five-membered Ring Compounds

α-Trifluoromethyl carbon radicals, generated by the tributyltin radical, added intramolecularly to oleginic double bonds to afford the trifluoromethyl-substituted five-membered ring compounds.

Efficient Carbonyl Addition of Polyfluorochloroethyl, -ethylidene, and -ethenyl Units by Means of 1,1,1-Trichloro-2,2,2-trifluoroethane and Zinc

Thermally stable zinc carbenoid CF3CCl2ZnCl was prepared from 1,1,1-trichloro-2,2,2-trifluoroethane and zinc powder in N,N-dimethylformamide and was allowed to add to carbonyls of aldehydes and α-keto esters in excellent yields to give 1-substituted 2,2-d