107692-05-7

Upstream product

• 42867-45-8 (dibromomethylene)triphenylphosphorane 
• 107692-04-6 (2R,3S)-(-)-3-benzyloxy-2-methylbutanal 
• 107692-02-4 (2R,3R)-2-methyl-1-(tetrahydropyran-2-yloxy)butan-2-ol 
• 107692-03-5 (2R,3R)-2-methyl-1-(tetrahydropyran-2-yloxy)butan-2-ol benzyl ether 
• 112996-11-9 (2S,3R)-(-)-3-benzyloxy-2-methylbutan-1-ol 

Downstream Products

• 107692-06-8 (3S,4R)-4-benzyloxy-3-methylpent-1-yne 
• 919114-50-4 2-(2-benzyloxy-1-methyl-propyl)-11-isopropoxy-5-methyl-1-oxa-benzo[a]anthracene-4,7,12-trione 
• 919114-49-1 2-(5-benzyloxy-4-methyl-hex-2-ynoyl)-1-hydroxy-8-isopropoxy-3-methyl-anthraquinone 
• 919114-48-0 2-(5-benzyloxy-4-methyl-hex-2-ynoyl)-1,8-diisopropoxy-3-methyl-anthraquinone 
• 919114-47-9 2-(5-benzyloxy-1-hydroxy-4-methyl-hex-2-ynyl)-1,8-diisopropoxy-3-methyl-anthraquinone 
• 919114-46-8 5-benzyloxy-1-(1,8-diisopropoxy-9,10-dimethoxy-3-methyl-anthracen-2-yl)-4-methyl-hex-2-yn-1-ol 
• 107692-10-4 (2R,2'R,3'S,6'S,8'R,10'R)-2,4-dimethyl-(10'-diphenyl-t-butylsiloxy-2',3'-dimethyl-1',7'-dioxaspiro<5.5>undecan-8-yl)-hex-4-enoyl 4S-(propan-2-yl)oxazolidin-2-one 
• 113016-73-2 (2R,2'R,3'S,6'S,8'R,10'R)-(+)-6-(10'-diphenyl-t-butylsiloxy-2',3'-dimethyl-1',7'-dioxaspiro<5.5>undecan-8'-yl)-2,4-dimethylhex-4-enyl toluene-p-sulphonate 
• 101212-45-7 (2R,3S,6S,10R)-(E)-(+)-10-diphenyl-t-butylsiloxy-8<(5'R)-3',5'-dimethyl-6'-phenylsulphonylhex-2'-enyl>-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan 
• 107865-54-3 (2R,3S,6S,8S,10S)-(+)-10-diphenyl-t-butylsilyloxy-2,3-dimethyl-8-(p-tolylsulphonyloxy)methyl-1,7-dioxaspiro<5.5>undecane 
• 101212-44-6 (2R,3S,6S,10R)-(E)-(+)-10-diphenyl-t-butylsiloxy-8<(5'R)-3',5'-dimethyl-6'thiophenylhex-2'-enyl>-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan 
• 112995-99-0 Methanesulfonic acid (E)-4-[(2R,4S,6R,8R,9S)-4-(tert-butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-2-methyl-but-2-enyl ester 
• 107692-07-9 (2'R,3'S,6'S,8'S,10'R)-(E)-(+)-ethyl 4-(10'diphenyl-t-butylsiloxy-2',3'-dimethyl-1',7'-dioxaspiro<5.5>undecane-8'-yl)-2-methylbut-2-enoate 
• 112320-69-1 (2R,2'R,3'S,6'S,8'R,10'R)-(+)-6-(10'-diphenyl-t-butylsiloxy-2',3'-dimethyl-1',7'-dioxaspiro<5.5>undecan-8'-yl)-2,4-dimethylhex-4-enol 

Relevant academic research and scientific papers

Enantioselective total synthesis and structure determination of the antiherpetic anthrapyran antibiotic AH-1763 IIa

(Chemical Equation Presented) The antiherpetic anthrapyran antibiotic (14S,16R)-AH-1763 IIa (see right-hand structure) and its (14R,16R) diastereomer have been prepared in enantioselective total syntheses. The relative and absolute stereochemistry of the

Preparation of a Chiral Lactone from Leavoglucosan; a Key Intermediate for Synthesis of the Spiroacetal Moietes of the Avermectins and Milbemycins

A synthesis of two diprotected (4S,6S)-4-hydroxy-6-hudroxymethyltetrahydropyran-2-ones has been developed from laevoglucosan.Reaction of these lactones with a substituted chiral lithium acetylide followed by hydrogenation and acid-catalysed cyclisation led to formation of the spiroacetal moiety of milbemycin α1 and α3.The acetylene was prepared by resolution of racemic material obtained from reaction of lithium acetylide and cis-butene epoxide.Alternatively a stereocontrolled synthesis was developed from (S)-methyl-3-hydroxy-2-methylpropionate which involved 'chelation controlled' addition of lithium dimethylcuprate to the corresponding tetrahydropyranyloxy aldehyde.

A FORMAL SYNTHESIS OF (+)MILBEMYCIN β3: A WITTIG APPROACH

A new route has been established to generate the C14-C15 trisubstituted double bond of milbemycin β3 by reaction of a Wittig reagent with the appropriate spiroacetal aldehyde.The product of this reaction, after conversion to the iodide and enan