113016-73-2

Upstream product

• 112320-69-1 (2R,2'R,3'S,6'S,8'R,10'R)-(+)-6-(10'-diphenyl-t-butylsiloxy-2',3'-dimethyl-1',7'-dioxaspiro<5.5>undecan-8'-yl)-2,4-dimethylhex-4-enol 
• 98-59-9 p-toluenesulfonyl chloride 
• 107692-06-8 (3S,4R)-4-benzyloxy-3-methylpent-1-yne 
• 107692-05-7 (3S,4R)-(+)-4-benzyloxy-1,1-dibromo-2-methylpent-1-ene 
• 88096-48-4 (2R,3S,6S,8S,10S)-(+)-10-hydroxy-8-hydroxymethyl-2,3-dimethyl-1,7-dioxaspiro<5.5>undecane 
• 107692-11-5 (2R,3S,6S,8S,10S)-(+)-2,3-dimethyl-10-hydroxy-8-(p-tolylsulphonyloxy)methyl-1,7-dioxaspiro<5.5>undecane 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 82415-18-7 (2S,4S,6S,8R,9S)-4-<(tert-butyldiphenylsilyl)oxy>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane-2-methanol 
• 82415-05-2 (2S,4S,6S,8R,9S)-4-(tert-Butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undecane-2-carbaldehyde 
• 107692-10-4 (2R,2'R,3'S,6'S,8'R,10'R)-2,4-dimethyl-(10'-diphenyl-t-butylsiloxy-2',3'-dimethyl-1',7'-dioxaspiro<5.5>undecan-8-yl)-hex-4-enoyl 4S-(propan-2-yl)oxazolidin-2-one 
• 107865-54-3 (2R,3S,6S,8S,10S)-(+)-10-diphenyl-t-butylsilyloxy-2,3-dimethyl-8-(p-tolylsulphonyloxy)methyl-1,7-dioxaspiro<5.5>undecane 
• 112995-99-0 Methanesulfonic acid (E)-4-[(2R,4S,6R,8R,9S)-4-(tert-butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-2-methyl-but-2-enyl ester 
• 107692-07-9 (2'R,3'S,6'S,8'S,10'R)-(E)-(+)-ethyl 4-(10'diphenyl-t-butylsiloxy-2',3'-dimethyl-1',7'-dioxaspiro<5.5>undecane-8'-yl)-2-methylbut-2-enoate 
• 107692-08-0 (2'R,3'S,6'S,8'R,10'R)-(E)-(+)-4-(10'diphenyl-t-butylsiloxy-2',3'-dimethyl-1',7'-dioxaspiro<5.5>undecan-8'-yl)-2-methylbut-2-enol 

Downstream Products

• 101212-45-7 (2R,3S,6S,10R)-(E)-(+)-10-diphenyl-t-butylsiloxy-8<(5'R)-3',5'-dimethyl-6'-phenylsulphonylhex-2'-enyl>-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan 
• 101212-47-9 methyl 2-<(6'R)-(10-diphenyl-t-butylsiloxy-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan-8-yl)-6',8'-dimethyldecan-2',4',8'-trien-2'-yl>-4-methoxy-5-methylbenzoate 
• 101212-46-8 2-{(1E,7E)-(R)-4-Benzenesulfonyl-3-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester 
• 82045-56-5 methyl 2-<(6R)-10-(10-hydroxy-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan-8-yl)-6,8-dimethyldecan-2,4,8-trien-2-yl>-4-methoxy-5-methylbenzoate 
• 101212-44-6 (2R,3S,6S,10R)-(E)-(+)-10-diphenyl-t-butylsiloxy-8<(5'R)-3',5'-dimethyl-6'thiophenylhex-2'-enyl>-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan 

Relevant academic research and scientific papers

Total Synthesis of (+)-Milbemycin β3

The total synthesis of (+)-milbemycin β3 has been achieved in two ways beginning from the appropriate spiroacetal moiety.In the first, coupling of a vinyl-lithium derivative (18) with the spiroacetal aldehyde (19), available from Swern oxidatio

A FORMAL SYNTHESIS OF (+)MILBEMYCIN β3: A WITTIG APPROACH

A new route has been established to generate the C14-C15 trisubstituted double bond of milbemycin β3 by reaction of a Wittig reagent with the appropriate spiroacetal aldehyde.The product of this reaction, after conversion to the iodide and enan