42867-45-8Relevant academic research and scientific papers
A straightforward synthesis of glyco-2,7- and 2,8-dienes
Dolhem, Franck,Smiljanic, Nicolas,Lièvre, Catherine,Demailly, Gilles
, p. 7756 - 7761 (2006)
In this paper, we report the efficient preparation of carbohydrate-derived 2,7- and 2,8-dienes. By our synthetic approach, we have quickly converted d-glucose 1 to (E)-ethyl-2,3-dideoxy-d-gluco-oct-2-enoate 5, which led to the desired (E)-ethyl-9,9-dibrom
Radical-mediated cyclization of a 6-chloro-9-(2-deoxy-D-erythro-pent-1- enofuranosyl)-8-(2,2-dibromovinyl)purine
Kittaka, Atsushi,Yamada, Naoki,Tanaka, Hiromichi,Nakamura, Kazuo T.,Miyasaka, Tadashi
, p. 1447 - 1457 (1996)
A vinyl radical generated from a 6-chloro-9-(2-deoxy-D-erythro-pent-1- enofuranosyl)-8-(2,2-dibromovinyl)purine effected cyclization either at the 1'- or at the 2'-position. The result is discussed in comparison with our previous study of the correspondin
Total synthesis of (-)-petrosiol e
Wang, Linlin,Zhang, Xing,Liu, Jun,Du, Yuguo
, p. 8231 - 8235 (2014)
(-)-Petrosiol E, a metabolite of sponge Petrosia strongylata, has been synthesized in 32% overall yield from cheap natural d-xylose in 10 steps. Our strategy provides an efficient way for the total synthesis of other petrosiol members, featuring the three
Synthetic efforts toward the synthesis of octalactins
Dinh, Minh-Thu,Bouzbouz, Samir,Péglion, Jean-Louis,Cossy, Janine
, p. 5703 - 5710 (2008)
Octalactin B was synthesized from the commercially available methyl-3-butenoate and isobutyraldehyde, using enantioselective allyl- and crotyltitanations to control the stereogenic centers at C3, C4, C7, C8, and C13. Moreover, the two other key-step react
REACTION OF TRIPHENYLPHOSPHINE-CARBON TETRAHALIDE REAGENT WITH α-KETO-γ-LACTONE
Suda, Minoru,Fukushima, Asako
, p. 103 - 106 (1981)
Triphenylphosphine-carbon tetrahalide reagent reacts with 4,4-dimethyloxolan-2,3-dione to afford two dihalomethyleneoxolanes, 8 and 9.The major reaction course can be changed by the addition order of the reagents.Reaction mechanisms are discussed.
New porphyrin dendrimers with fluorenyl-based connectors: a simple way to improving the optical properties over dendrimers featuring 1,3,5-phenylene connectors
Zhang, Xu,Ben Hassine, Sarra,Richy, Nicolas,Mongin, Olivier,Blanchard-Desce, Mireille,Paul, Frédéric,Paul-Roth, Christine O.
, p. 4144 - 4157 (2020/03/19)
Two new meso-tetrafluorenylporphyrin-cored dendrimers 1 and 2 have been synthesized and characterized. The peripheral fluorenyl units of these dendrimers are linked to the central tetrafluorenylporphyrin (TFP) core by original fluorene-based connectors instead of the more classic 1,3,5-phenylene unit. Selected linear and non-linear optical (LO and NLO) properties were determined for these dendrimers via absorption or emission studies and by two-photon excited fluorescence (TPEF) measurements. Dendrimer 1, which has a conjugated and quite rigid structure, exhibits a significantly higher two-photon absorption (2PA) cross-section than dendrimer 2, presenting a non-conjugated and more flexible structure, as well as better luminescence and singlet oxygen activation quantum yields. Both dendrimers exhibit higher 2PA cross-sections than several closely related TFP-based dendrimers previously characterized. However, among them, dendrimer 1 is the only one outperforming all these compounds in terms of 2PA brightness and 2PA oxygen sensitization. Thus, the new type of connector (or dendrimeric node) introduced in 1 appears to be quite appealing for the design of photosensitizers aimed at theranostic uses in the future.
Synthesis of Tetradecapentaenoic Acid Derivatives
Kolodyazhnaya,Kolodyazhny
, p. 1998 - 2004 (2019/11/29)
A 12-stage method for the stereoselective synthesis of tetradecapentaenoic acid derivatives using phosphoric reagents was developed. The key step in the synthesis is the Z-selective Wittig reaction between sorbaldehyde and triphenylphosphonium (6-methoxycarbonyl)hexanilide, as well as the Ramirez-Corey-Fuchs reaction and the Trost-Kazmaier rearrangement. The synthesized (2E,4E,8Z,10E,12E)-N-isobutyltetradeca-2,4,8,10,12-pentaenamide corresponds to a natural compound called γ-Sansho?l.
Synthesis, characterization and antimicrobial evaluation of new cis-bicyclo [3.3.0] octane-3,7-dione derivatives
El-Sayed, Naglaa F.,Ewies, Ewies F.,Boulos, Leila S.,Mohram, Maysa E.
, p. 277 - 289 (2017/06/08)
NEWLY synthesized bicyclo[3.3.0]octane-3,7-dione derivatives were evaluated for their antimicrobial activity. These compounds were prepared from reactions of cis-bicyclo[3.3.0]octane-3,7-dione with stabilized phosphorus ylides, (2-oxovinylidene)triphenylphosphorane, tris(dialkylamino)phosphines, as well as with Lawesson's and Japanese reagents and their structures were confirmed on the basis of spectroscopic and elemental analyses.
Synthesis of novel pyrazole derivatives using organophosphorus, stibine, and arsine reagents and their antitumor activities
El-Sayed, Naglaa F.,Ewies, Ewies F.,El-Hussieny, Marwa,Boulos, Leila S.,Shalaby, ElSayed M.
, p. 765 - 776 (2016/07/27)
The reactions of 5-azido-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (azidopyrazole) with several classes of organophosphorus reagents: phosphonium ylides, Wittig-Horner reagents, dialkylphosphonates, trialkylphosphites, tris(dialkylamino)phosphanes, triphenylstibane, triphenylarsane, and Lawesson's reagent are reported. Structural reasoning for the new products was based on compatible analytical and spectral data. The cytotoxic activity of most of the new products was evaluated against human breast carcinoma cell line (MCF7) and human hepatocellular carcinoma cell line(HepG2). Certain tested compounds showed promising results.
PYRAZOLE SUBSTITUTED IMIDAZOPYRAZINES AS CASEIN KINASE 1 D/E INHIBITORS
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Page/Page column 154, (2014/07/08)
The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.
