107699-52-5

Upstream product

• 616-45-5 2-pyrrolidinon 
• 93607-94-4 1-phenylmethyl 5-fluoro 1-H-tetrazole 
• 305791-50-8 N-benzyl-2-oxopyrrolidine-1-carbothioamide 
• 54680-34-1 azoture de l'acide (phenylmethyl) carbamique 
• 16956-42-6 N-(phenylmethyl) hydrazine carboxamide 
• 3173-56-6 benzyl isothiocyanate 
• 93608-00-5 1-phenylmethyl 5-chloro 1H-tetrazole 
• 6181-92-6 dichlorure de l'acide N-(phenylmethyl) carbonimidique 
• 88333-03-3 Benzyl isocyanide 

Relevant academic research and scientific papers

A general synthetic method for the formation of substituted 5-aminotetrazoles from thioureas: a strategy for diversity amplification.

A general method for the synthesis of 5-aminotetrazoles is outlined using the mercury(II)-promoted attack of azide anion on a thiourea. The reaction proceeds through a guanyl azide intermediate, which undergoes electrocyclization to the tetrazole. The method is high yielding and provides access to mono-, di-, and trisubstituted 5-aminotetrazoles, targets of potential interest for combinatorial library development.

SYNTHESE DE N-(TETRAZOL-5-YL) AZETIDIN-2-ONES

N-(tetrazol-5-yl) azetidin-2-ones can be conveniently prepared by reacting N-unsubstituted beta-lactams with 1-benzyl 5-fluoro 1H-tetrazole