1077-94-7

Basic information

• Product Name: 5-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID
• Synonyms: 1H-INDAZOLE-3-CARBOXYLIC ACID, 5-BROMO-;5-BROMOINDAZOLE-3-CARBOXYLIC ACID;5-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID;5-BROMO-3-INDAZOLECARBOXYLIC ACID;5-BroMo-1H-indazole-3-car...;5-Bromo-3-carboxy-1H-indazole;5-broMo-1H-indazol-3-carboxylic acid
• CAS NO: 1077-94-7
• Molecular Formula: C₈H₅BrN₂O₂
• Molecular Weight: 241.04
• Product Categories: pharmacetical;Indazole;Building Blocks
• Mol File: 1077-94-7.mol
• Article Data: 17

Chemical Properties

• Melting Point: 289-292°C
• Boiling Point: 493.361 °C at 760 mmHg
• Flash Point: 252.176 °C
• Appearance: /
• Density: 1.947 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.766
• Storage Temp.: 2-8°C
• PKA: 2.81±0.30(Predicted)
• CAS DataBase Reference: 5-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID(1077-94-7)
• EPA Substance Registry System: 5-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID(1077-94-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Safety Statements: 22-26-36/37/39
• Hazardous Substances Data: 1077-94-7(Hazardous Substances Data)

Usage

General Description

5-Bromo-1H-indazole-3-carboxylic acid is a chemical compound with the molecular formula C9H6BrN3O2. It is a derivative of indazole, an aromatic heterocyclic organic compound. This chemical is a carboxylic acid, and its structure contains a bromine atom attached to the indazole ring. It is primarily used as a building block in the synthesis of various pharmaceuticals and agrochemicals, and it is also utilized in research and development of new chemical entities. 5-Bromo-1H-indazole-3-carboxylic acid has potential applications in the field of medicinal chemistry for the creation of novel compounds with therapeutic properties.

InChI:InChI=1/C8H5BrN2O2/c9-4-1-2-6-5(3-4)7(8(12)13)11-10-6/h1-3H,(H,10,11)(H,12,13)

Upstream product

• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 16917-43-4 benzaldehyde 4-bromophenylhydrazone 
• 4498-67-3 1H-Indazole-3-carboxylic acid 

Downstream Products

• 53857-57-1 5-bromo-1H-indazole 
• 78155-74-5 5-bromo-1H-indazole-3-carboxylic acid methyl ester 
• 910904-74-4 C₁₈H₁₈BrN₃O₃ 
• 1799421-04-7 5-bromo-1H-indole-3-carboxamide 
• 886363-74-2 1-(5-bromo-1H-indazol-3-yl)ethan-1-one 
• 910904-82-4 C₃₀H₃₁N₃O₅ 
• 910904-77-7 C₂₅H₂₄BrN₃O₃ 

Relevant articles and documents

Heteroaromatic ring compound and application thereof

The invention relates to a heteroaromatic ring compound and application thereof. Specifically, the invention provides a compound shown as a formula I, or an optical isomer or raceme thereof, or a pharmaceutically acceptable salt thereof. The compound prov

INDAZOLE CONTAINING MACROCYCLES AND THERAPEUTIC USES THEREOF

Indazole macrocycle compounds of formula (I) for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole macrocycle compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states. Formula (I)

Synthetic method of 5-substituted indazole-3-carboxylic acid

The invention provides a synthesis method of 5-substituted indazole-3-carboxylic acid, and belongs to the field of pharmaceutical chemical synthesis, wherein R=hydrogen, alkyl, alkoxy, trifluoroalkoxyand halogen. A phenylhydrazine compound 3 is taken as a