107753-00-4

Usage

Molecular Weight

349.8 g/mol

Functional Groups

Amino group (NH2)
Chlorophenyl group (4-ClC6H4)
Carbonyl group (C=O)
Carbonitrile group (C≡N)

Structure

Contains a chromene ring
Substituted at positions 2, 4, 7, and 7 with amino, chlorophenyl, dimethyl, and oxo groups respectively

Potential Biological Activities

Due to its complex structure and functional groups, it may exhibit diverse biological activities

Applications

Pharmaceutical industry: Likely used in drug development and medicinal chemistry

Properties

Organic compound: Indicates carbon-based structure
Chromene ring: Suggests potential pharmacological activity
Carbonitrile group: May confer specific chemical reactivity and biological properties

Need for Further Research

Despite its potential, additional studies are required to comprehensively understand its properties and applications.

Upstream product

• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 126-81-8 dimedone 
• 104-88-1 4-chlorobenzaldehyde 
• 109-77-3 malononitrile 
• 2235-08-7 Propargyl nitrile 
• 3471-13-4 dimedone 
• 622-95-7 4-chlorobenzyl bromide 

Downstream Products

• 242481-12-5 ethyl N-(4-(4-chlorophenyl)-3-cyano-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-2-yl)formimidate 
• 242481-20-5 3-amino-4-imino-8,8-dimethyl-5-(4-chlorophenyl)-3,4,5,6,7,9-hexahydro-8H-6-oxo-chromeno[2,3-d]pyrimidine 
• 242481-16-9 4-imino-8,8-dimethyl-5-(4-chlorophenyl)-3-benzyl-3,4,5,6,7,9-hexahydro-8H-6-oxo-chromeno[2,3-d]pyrimidine 
• 1229931-74-1 4-(4-chlorophenyl)-5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-2-(phenylamino)quinoline-3-carbonitrile 
• 1610831-52-1 3-(4-chlorophenyl)-2-cyano-6,6-dimethyl-4-oxo-2,3,4,5,6,7-hexahydrobenzofuran-2-carboxamide 

Relevant academic research and scientific papers

2-amino-4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen e-3-carbonitrile

The supramolecular structure of C18H17ClN2O2 was studied. The structure was determined by the intersection of two chains formed by N-H···O and N-H···N hydrogen bonds, forming a two-dimensional sheet. A solution

A facile and efficient synthesis of tetrahydrobenzo[b]pyrans using lactose as a green catalyst

Lactose has been used as a mild, efficient, green, and inexpensive catalyst for the synthesis of tetrahydrobenzo[b]pyran derivatives via a one-pot, three-component condensation between aryl aldehydes, malononitrile, and dimedone in H2O:EtOH at

Synthesis and characterization of a novel and green rod-like magnetic ZnS/CuFe2O4/agar organometallic hybrid catalyst for the synthesis of biologically-active 2-amino-tetrahydro-4H-chromene-3-carbonitrile derivatives

The magnetic biocompatible rod-like ZnS/CuFe2O4/agar organometallic hybrid catalyst was designed and prepared based on a natural macromolecule (agar) through a green and convenient method using inexpensive, nontoxic, and easily avail

A green one-pot multicomponent synthesis of 4H-pyrans and polysubstituted aniline derivatives of biological, pharmacological, and optical applications using silica nanoparticles as reusable catalyst

A one-pot practical, efficient, and environmentally benign multicomponent synthesis of 4H-pyrans and polysubstituted aniline derivatives of biological, pharmacological, and optical applications has been developed using a very mild, neutral, and reusable s

Sodium ethylene diamine tetraacetate catalyzed synthesis of chromene derivatives via multi-component reactions at low catalyst loading

An efficient and practical protocol for the synthesis of chromenes derivatives catalyzed by a low-loading sodium ethylene diamine tetraacetate (2?mol%) as a catalyst via multicomponent reaction is reported. A wide range of aromatic aldehydes easily underg

Three VO2+ complexes of the pyridoxal-derived Schiff bases: Synthesis, experimental and theoretical characterizations, and catalytic activity in a cyclocondensation reaction

Three oxovanadium(IV) complexes of the pyridoxal Schiff bases have been newly synthesized and characterized. The used Schiff bases were N,N′-dipyridoxyl(ethylenediamine), N,N′-dipyridoxyl(1,3-propanediamine) and N,N′-dipyridoxyl(1,2-benzenediamine). Also, the optimized geometry, assignment of the IR bands and the Natural Bond Orbital (NBO) analysis of the complexes have been computed using the density functional theory (DFT) methods. Dianionic form of the Schiff bases (L2?) acts as a tetradentate N2O2 ligand. The coordinating atoms of the Schiff base are the phenolate oxygens and imine nitrogens, which occupy four base positions of the square-pyramidal geometry of the complexes. The oxo ligand occupies the apical position of the [VO(L)] complexes. In the optimized geometry of the complexes, the coordinated Schiff bases have more planar structure than their free form. Due to the high-energy gaps, all of the complexes are predicted to be stable. Good agreement between the experimental values and the DFT-computed results supports suitability of the optimized geometries for the complexes. The investigated complexes show high catalytic activities in synthesis of the tetrahydrobenzo[b]pyrans through a three-component cyclocondensation reaction of dimedone, malononitrile and some aromatic aldehydes. The complexes catalyzed the reaction in solvent free conditions and the catalysts were found to be reusable.

A green synthesis of tetrahydrobenzo[b]pyran derivatives through three-component condensation using N-methylimidazole as organocatalyst

An efficient and convenient approach to the synthesis of 2-amino-3-cyano-4-aryl-7,7-dimethyl-5-oxo-4H-5,6,7,8-tetrahydrobenzo[b]pyran derivatives using N-methylimidazole as the organocatalyst (20∈mol%) is described. This method has several advantages, suc

Visible light promoted synthesis of dihydropyrano[2,3-c] chromenes via a multicomponent-tandem strategy under solvent and catalyst free conditions

The development of unique, mild and efficient one pot, multicomponent-tandem synthesis of highly functionalized dihydropyrano[2,3-c]chromenes under photochemical activation is reported. The key feature of the present work is the utilization of visible lig

Green synthesis of Fe3O4/ZnO magnetic core-shell nanoparticles by Petasites hybridus rhizome water extract and their application for the synthesis of pyran derivatives: Investigation of antioxidant and antimicrobial activity

In this research, Fe3O4/ZnO magnetic core-shell nanoparticles (Fe3O4/ZnO MCNPs) were synthesized through a green method using Petasites hybridus rhizome water extract as a reducing and stabilizing agent. The mor

1-Methylimidazolium tricyanomethanide {[HMIM]C(CN)3} as a nano structure and reusable molten salt catalyst for the synthesis of tetrahydrobenzo[b]pyrans via tandem Knoevenagel-Michael cyclocondensation and 3,4-dihydropyrano[c]chromene derivativ

An expeditious, experimentally simple and rapid 1-methylimidazolium tricyanomethanide {[HMIM]C(CN)3} nano molten salt (NMS) catalyzed tandem Knoevenagel-Michael cyclocondensation procedure for the synthesis of tetrahydrobenzo[b]pyrans was descr