107756-05-8

Basic information

• Product Name: 2-ethylmercapto-5-nitro-pyridine
• Synonyms: 2-ethylmercapto-5-nitro-pyridine;2-Ethylsulfanyl-5-nitro-pyridine
• CAS NO: 107756-05-8
• Molecular Formula: C7H8N2O2S
• Molecular Weight: 184
• Mol File: 107756-05-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-ethylmercapto-5-nitro-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethylmercapto-5-nitro-pyridine(107756-05-8)
• EPA Substance Registry System: 2-ethylmercapto-5-nitro-pyridine(107756-05-8)

Safety Data

• Hazardous Substances Data: 107756-05-8(Hazardous Substances Data)

Usage

General Description

2-Ethylmercapto-5-nitro-pyridine is a chemical compound that has a molecular formula of C7H8N2O2S. It is a yellow solid with a molecular weight of 188.22 g/mol and is classified as an organosulfur compound. 2-ethylmercapto-5-nitro-pyridine is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and pigments. Additionally, it has been identified as an inhibitor of metalloprotease enzymes, making it a potential candidate for therapeutic agents targeting metalloprotease-associated diseases such as cancer and inflammation. It is important to handle this chemical with care as it may be hazardous if not properly controlled and managed.

InChI:InChI=1S/C7H8N2O2S/c1-2-12-7-4-3-6(5-8-7)9(10)11/h3-5H,2H2,1H3

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 75-08-1 ethanethiol 
• 2127-09-5 2-mercapto-5-nitropyridine 
• 75-03-6 ethyl iodide 
• 811-51-8 sodium thioethylate 

Downstream Products

• 1198785-11-3 (6-ethylsulfanylpyridin-3-yl)carbamic acid tert-butyl ester 
• 118420-46-5 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(6-ethylsulfanyl-pyridin-3-yl)-acrylamide 

Relevant articles and documents

GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

Compounds of Formula I wherein R1, R2, X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamides

A new series of 3-(3-pyridyl)acrylamides 16, 17, 19, and 26, and 5-(3-pyridyl)-2,4-pentadienamides 20-25 were prepared and evaluated for their antiallergic activity. Several of these compounds exhibited more potent inhibitory activities than the parent compounds 1a [(E)-N-[4 [4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamide] against the rat passive cutaneous anaphylaxis (PCA) reaction and the enzyme 5-lipoxygenase. Particularly, 4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(6-methyl-3-pyridyl)acrylamide (17p) showed an ED50 value of 3.3 mg/kg po in the rat PCA test, which was one-fifth of ketotifen and oxatomide. As compared with ketotifen and oxatomide, compound 17p (AL-3264) possessed a better balance of antiallergic properties due to inhibition of chemical mediator release, inhibition of 5-lipoxygenase, and antagonism of histamine.