107832-65-5Relevant academic research and scientific papers
Metallation reactions. Part 35: A change of the regiochemistry in the metallation of (alkylthio)arenes
Cabiddu, Maria G.,Cabiddu, Salvatore,Cadoni, Enzo,De Montis, Stefania,Fattuoni, Claudia,Melis, Stefana
, p. 3915 - 3920 (2007/10/03)
The metallation reaction of bromo(alkylthio)benzenes is described. The results show the complementarity of these reactions with the metal-hydrogen exchange reaction. In fact, monometallation of bromo(methylthio)benzenes afforded products substituted in para or meta or ortho to the thioethereal function while bimetallation led to αS,para, αS,meta and αS,ortho disubstituted products. Analogously, the monometallation of 4-bromo-(isopropylthio)benzene afforded para-monosubstituted and ortho,para-disubstituted products.
METALATION REACTIONS. IX. DILITHIATION OF AROMATIC THIOETHERS
Cabiddu, Salvatore,Floris, Constantino,Melis, Stefana
, p. 4625 - 4628 (2007/10/02)
Direct dimetalation of aromatic thioethers gives with good yield the dilithiated species 3, 4, 17, 18, 25, 26.The first four species allowed the simultaneous introduction of an electrophile in the thiomethyl group and in the ring, while the last two species undergo disubstitution in the ring.
