1079340-26-3

Basic information

• Product Name: C₃₈H₅₆O₃
• CAS NO: 1079340-26-3
• Molecular Weight: 560.861
• Mol File: 1079340-26-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₈H₅₆O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₈H₅₆O₃(1079340-26-3)
• EPA Substance Registry System: C₃₈H₅₆O₃(1079340-26-3)

Safety Data

• Hazardous Substances Data: 1079340-26-3(Hazardous Substances Data)

Upstream product

• 1724-17-0 oleanolic acid methyl ester 
• 100-39-0 benzyl bromide 

Downstream Products

• 1079340-11-6 (4aS,6aS,6bR,10S,12aR)-10-(benzyloxy)-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid 

Relevant articles and documents

Oleanolic acid and its derivatives: New inhibitor of protein tyrosine phosphatase 1B with cellular activities

Protein tyrosine phosphatase 1B is a key factor in the negative regulation of insulin pathway and a promising target for treatment of diabetes and obesity. Herein, a series of competitive inhibitors were optimized from oleanolic acid, a natural triterpenoid identified against PTP1B by screening libraries of traditional Chinese medicinal herbs. Modifying at 3 and 28 positions, we obtained compound 13 with a Ki of 130 nM, which exhibited good selectivity between other phosphatases involved in insulin pathway except T-cell protein tyrosine phosphatase. Further evaluation in cell models illustrated that the derivatives enhanced insulin receptor phosphorylation in CHO/hIR cells and also stimulated glucose uptake in L6 myotubes with or addition of without insulin.