1724-17-0Relevant articles and documents
Water-induced gel formation of an oleanlic acid-adenine conjugate and the effects of uracil derivative on the gel stability
Lu, Jinrong,Hu, Jun,Liu, Chulong,Gao, Hongxin,Ju, Yong
, p. 9576 - 9580,5 (2012)
The conjugate of oleanlic acid with adenine was synthesized and it could be gelled in mixed solvents of THF and water, but no gel was formed in the single organic solvent. The self-aggregation behaviour and physical properties of the organogel were characterized by 1H NMR, FT-IR, and scanning electron microscopy. The morphology and the stability of the gel were remarkably affected by the uracil derivative through destroying hydrogen-bonding.
Studies on differentiation-inducing activities of triterpenes
Umehara,Takagi,Kuroyanagi,Ueno,Taki,Chen
, p. 401 - 405 (1992)
Differentiation-inducing activity of over 180 extracts of crude drugs and plants was tested using mouse myeloid leukemia cell line (M1). The methanol extracts of clove (Syzygium aromaticum MERRILL et PERRY, Myrtaceae) showed remarkable induction of differentiation of M1 cells into macrophage-like cells. From the extract, oleanolic acid (1) and crategolic acid (2) were isolated as the active components. We also tested other triterpenes, such as oleananes, ursanes and dammaranes, to investigate the structure-activity relationship. Some triterpene aglycones showed differentiation inducing activity, but triterpene glycosides showed little activity. Furthermore, the differentiation-inducing activity of these triterpene compounds was tested against human acute promyelocytic leukemia cell line (HL-60).
TWO SAPONINS FROM ZEXMENIA BUPHTHALMIFLORA
Schteingart, Claudio D.,Pomilio, Alicia B.
, p. 2907 - 2910 (1984)
Oleanolic acid 3-O-(3'-O-α-L-rhamnopyranosyl)-β-D-glucuronopyranoside and its 28-O-β-D-glucopyranosyl ester have been isolated from aerial parts of Zexmenia buphthalmiflora.The chemotaxonomical significance of the transfer of Wedelia buphthalmiflora to Zexmenia buphthalmiflora is discussed. Key Word Index - Zexmenia buphthalmiflora; Wedelia buphthalmiflora; Heliantheae; Compositae; structure elucidation; saponins; oleanolic acid 3-O-(3'-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside; oleanolic acid 3-O-(3'-O-α-L-rhamnopyranosyl)-β-D-glucuronopyranoside-28-O-β-D-glucopyranoside.
Partial synthesis of krukovines A and B, triterpene ketones isolated from the Brazilian medicinal plant Maytenus krukovii
Honda,Finlay,Gribble
, p. 1174 - 1177 (1997)
Krukovines A (1) and B (2), triterpene ketones isolated from the Brazilian medicinal plant 'chuchuhuasi' (Maytenus krukovii), were synthesized in eight steps from the commercially available oleanolic acid and ursolic acid, respectively.
Synthesis and anion recognition of a novel oleanolic acid-based cyclic dimer
Hu, Jun,Li, Ruofan,Lu, Jinrong,Ju, Yong
, p. 4211 - 4214 (2011)
A novel cyclic dimer based on oleanolic acid was synthesized using click chemistry and it showed remarkable selectivity and affinity to bind fluoride ion through C-H...F hydrogen bond interactions which involved the delocalization of proton in methylene.
Radical-Induced Deoxygenation of Primary Alcohols
Barton, Derek H. R.,Motherwell, William B.,Stange, Andreas
, p. 743 - 745 (1981)
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Patkhullaeva et al.
, (1972)
On the saponins from the leaves of Fatsia japonica Decne. et Planch.
Tomimori,Kizu
, p. 92 - 94 (1979)
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Type and position of linkage govern the cytotoxicity of oleanolic acid rhodamine B hybrids
Heise, Niels,Hoenke, Sophie,Simon, Vivienne,Deigner, Hans-Peter,Al-Harrasi, Ahmed,Csuk, René
, (2021/06/21)
Oleanolic acid/rhodamine B hybrids exhibit different cytotoxicity depending on the way these two structural elements are linked. While a hybrid holding a piperazinyl spacer at C-28 proved to be cytotoxic in the nano-molar concentration range, hybrids with a direct linkage of the Rho B residue to C-3 of the triterpenoid skeleton are cytotoxic only in the low micro-molar concentration range without any selectivity. This once again underlines the importance of selecting the right spacer and the most appropriate position on the skeleton of the triterpene to achieve the most cytotoxic hybrids possible.
Application of methyl isocycloenone oleanolate to preparation of medicine for preventing and treating viral hepatitis B
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Paragraph 0029; 0032-0033, (2020/11/23)
The invention relates to an application of methyl isocycloenone oleanolate to preparation of a medicine for preventing and treating viral hepatitis B, and particularly provides an application of 3 beta-hydroxyl-12-carbonyl oleanane-13 (18)-alkene-28-carboxylic acid methyl ester to preparation of a medicine for resisting hepatitis B virus infection diseases. A compound has remarkable effect of inhibiting the activity of HBsAg and HBeAg secreted by HepG2.2. 15 cells, the intensity of inhibiting HBsAg and HBeAg secretion at the concentration of 100 micrograms/milliliter on the eighth day exceedsthat of positive control medicines namely alpha-interferon and lamivudine, and the inhibition rate of the compound on HBV-DNA replication is higher than 97% under the concentration. The result shows that the methyl isocycloenone oleanolate can be expected to be used for preparing non-nucleoside medicines for treating hepatitis B virus infection diseases; and specifically, the compound has the functions of being used for preparing an HBV-DNA inhibitor, an HBsAg inhibitor and an HBeAg inhibitor, and the preparation method is simple in step, low in cost, wide in raw material source and easy for industrial production.