107938-40-9Relevant academic research and scientific papers
DIARYLTHIOHYDANTOIN COMPOUND AS ANDROGEN RECEPTOR ANTAGONIST
-
Paragraph 0641-0643, (2020/07/07)
The present application belongs to the field of medicine. In particular, the present application relates to a diarylthiohydantoin compound as an androgen receptor antagonist or a pharmaceutically acceptable salt thereof, a preparation method of the same, a pharmaceutical composition comprising the compound, and a use thereof in treating a cell proliferative disease mediated by androgen. The compound of the present application has good antagonistic effect on androgen receptor and exhibits excellent antitumor effect.
Organocatalytic asymmetric hydrolysis of epoxides
Monaco, Mattia Riccardo,Prevost, Sebastien,List, Benjamin
supporting information, p. 8142 - 8145 (2014/08/18)
The hydrolytic ring opening of epoxides is an important biosynthetic transformation and is also applied industrially. We report the first organocatalytic variant of this reaction, exploiting our recently discovered activation of carboxylic acids with chiral phosphoric acids via heterodimerization. The methodology mimics the enzymatic mechanism, which involves an enzyme-bound carboxylate nucleophile. A newly designed phosphoric acid catalyst displays high stereocontrol in the desymmetrization of meso-epoxides. The methodology shows wide generality with cyclic, acylic, aromatic, and aliphatic substrates. We also apply our method in the first highly enantioselective anti-dihydroxylation of simple olefins.
Selective Manipulation of Hydroxy Groups in (2S,3S)-Threitol
Takano, Seiichi,Kurotaki, Ayako,Sekiguchi, Yoshinori,Satoh, Shigeki,Hirama, Michiyasu,Ogasawara, Kunio
, p. 811 - 817 (2007/10/02)
Systematic transformation of diethyl (2R,3R)-tartrate into a number of protected or functionalized derivatives of threitol, which are important precursors for many natural products, is carried out employing reductive and oxidative cleavage reactions of be
