107941-23-1

Upstream product

• 52289-93-7 o-Methoxybenzyl bromide 
• 1066-54-2 trimethylsilylacetylene 
• 61210-52-4 (trimethylsilyl)ethynylmagnesium bromide 
• 7035-02-1 o-Methoxybenzyl chloride 

Downstream Products

• 73234-87-4 1-methoxy-2(2-propynyl)benzene 
• 73234-94-3 1-methoxy-2-(propa-1,2-dien-1-yl)benzene 
• 1338461-18-9 C₂₄H₂₄O₃ 
• 107941-24-2 methyl 4-(2-methoxy-phenyl)-2-butynoate 

Relevant academic research and scientific papers

Cobalt-catalyzed benzyl-alkynyl coupling

Benzylic halides coupled with 1-alkynylmagnesium halides in the presence of a catalytic amount of Co(acac)3 to provide 1-aryl-2-alkynes in moderate to good yield.

Ortho-Bromo(propa-1,2-dien-1-yl)arenes: Substrates for domino reactions

o-Bromo(propa-1,2-dien-1-yl)arenes exhibit novel and orthogonal reactivity under Pd catalysis in the presence of secondary amines to form enamines (concerted Pd insertion, intramolecular carbopalladation, and terminative Buchwald-Hartwig coupling) and of amides to form indoles (addition, Buchwald-Hartwig cyclization, and loss of the acetyl group). The substrates for these reactions can be accessed in a reliable and highly selective two-step process from 2-bromoaryl bromides.