1338461-18-9Relevant academic research and scientific papers
Ortho-Bromo(propa-1,2-dien-1-yl)arenes: Substrates for domino reactions
Masters, Kye-Simeon,Wallesch, Manuela,Braese, Stefan
, p. 9060 - 9067 (2011/12/03)
o-Bromo(propa-1,2-dien-1-yl)arenes exhibit novel and orthogonal reactivity under Pd catalysis in the presence of secondary amines to form enamines (concerted Pd insertion, intramolecular carbopalladation, and terminative Buchwald-Hartwig coupling) and of amides to form indoles (addition, Buchwald-Hartwig cyclization, and loss of the acetyl group). The substrates for these reactions can be accessed in a reliable and highly selective two-step process from 2-bromoaryl bromides.
