107941-39-9Relevant academic research and scientific papers
Heck reaction: Stereo selective synthesis of trisubstituted olefins: Useful intermediates for anthraquinone carboxylic acid derivatives
Rama Devi,Rajaram
, p. 591 - 597 (2007/10/03)
Palladium catalyzed arylation of dialkyl itaconate in presence of Pd(OAc)2/PPh3 as a catalyst, afforded trisubstituted olefins stereo selectively. These alkenes are useful intermediates for the synthesis of anthraquinone carboxylic acid derivatives. A new coumarin is also synthesized using this protocol.
Regiospecific synthesis of polysubstituted naphthalenes and iodoacylnaphthoquinones via zirconocene complexes of naphthalynes
Buchwald, Stephen L.,King, Susan M.
, p. 258 - 265 (2007/10/02)
Zirconocene complexes of substituted naphthalynes have been generated in situ and trapped with nitriles to form azametallacycles with excellent regiochemical control. These compounds can be converted into ketones, α-iodo ketones, and iodoacylnaphthoquinon
Synthetic Approach to Aklavinone Using 2-Oxo-2H-pyran-5-carboxylate (Coumalate) Intermediates
Jung, Michael E.,Hagenah, Jeffrey A.
, p. 1889 - 1902 (2007/10/02)
A novel approach for the preparation of aklavinone 5 is described in which the key step is the cycloaddition of a substituted coumalate with a ketene acetal to produce a masked A ring with the C and D rings attached.The 4-(arylmethyl)coumalate 53 was prepared from naphthalene-1,5-diol (6) by a seven step route involving as the key step the cyclocondensation of the methyl (arylmethyl)propiolate 52 with methyl 3-oxopentanoate 10.Cycloaddition of 53 with dimethyl ketene acetal 12 produced the potential A-ring precursor 67, which could not be cleanly reduced, thereby ending this scheme.The preparation of functionalized 4,6-dialkylpyrone-5-carboxylates and their use in the synthesis of bicyclic lactones and substituted benzoates via cycloaddition reactions are also described.
