1079649-91-4

Upstream product

• 50-00-0 formaldehyd 
• 65-86-1 orotic acid 
• 75-31-0 isopropylamine 
• 4156-75-6 2,4-dihydroxyfuro[3,4-d]pyrimidin-7(5H)-one 
• 15572-56-2 isopropylamine hydrochloride 
• 6341-93-1 orotic acid 

Downstream Products

• 1079649-94-7 2,4-dichloro-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one 
• 1079664-08-6 C₂₂H₂₈N₆O₂ 
• 1079664-02-0 C₂₃H₃₀N₆O₂ 
• 1079653-89-6 C₂₃H₂₉ClN₆O₂ 
• 1079653-92-1 C₂₄H₃₂N₆O₂ 
• 1079653-27-2 C₂₄H₃₁ClN₆O₂ 
• 1079653-48-7 C₂₅H₃₃ClN₆O₂ 
• 1079653-46-5 C₂₆H₃₃ClN₆O₂ 
• 1079654-39-9 C₂₅H₃₃ClN₆O₂ 
• 1079655-25-6 2-(4-acetyl-piperazin-1-yl)-4-(4-chloro-benzylamino)-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]-pyrimidin-7-one 
• 1079657-75-2 2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(4-(trifluoromethyl)benzylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one 
• 1079653-74-9 2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-{[4-(trifluoromethoxy)benzyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one 
• 1079657-78-5 2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-(2-methoxy-4-(trifluoromethoxy)benzylamino)-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one 
• 1079653-78-3 2-(4-acetylpiperazin-1-yl)-6-isopropyl-4-{[(1R)-1-(4-methylphenyl)ethyl]amino}-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one 

Relevant academic research and scientific papers

FUSED PYRIMIDINE COMPOUNDS AS KCC2

The invention concerns compounds of Formula (I): (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R7 and ring A have any of the meanings hereinbefore defined in the description; process for their preparation; pharmaceutical compositions containing them and their use in treating KCC2 mediated diseases.

Discovery of P2X3 selective antagonists for the treatment of chronic pain

Purinergic receptor P2X3 has been linked to analgesia in a number of pre-clinical models of pain, and is expressed in the human pain perception pathway. Only few P2X3-selective antagonists have been reported to date. This Letter describes the SAR and in vivo analgesic profile of a novel scaffold of selective P2X3 antagonists.

PYRROLOPYRIMIDIN-7-ONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS

Compounds of formula (I) or pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, and R5 and are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.