1079655-40-5

Upstream product

• 6341-93-1 orotic acid 
• 1079649-94-7 2,4-dichloro-6-isopropyl-5H-pyrrolo[3,4-d]pyrimidin-7(6H)-one 
• 1209050-26-9 (R)-1-(4-Trifluoromethoxy-phenyl)-ethylamine 
• 1079649-91-4 2,4-dihydroxy-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one 
• 55276-43-2 4-methanesulfonylpiperazine 

Relevant academic research and scientific papers

Discovery of P2X3 selective antagonists for the treatment of chronic pain

Purinergic receptor P2X3 has been linked to analgesia in a number of pre-clinical models of pain, and is expressed in the human pain perception pathway. Only few P2X3-selective antagonists have been reported to date. This Letter describes the SAR and in vivo analgesic profile of a novel scaffold of selective P2X3 antagonists.