107997-34-2Relevant academic research and scientific papers
Synthesis, in-vitro microbial and cytotoxic studies of new benzimidazole derivatives
Harisha, Reddy S.,Hosamani, Kallappa M.,Keri, Rangappa S.
, p. 412 - 419 (2009)
Several new classes of benzimidazole derivatives were synthesized and evaluated for in-vitro antimicrobial and cytotoxic activities. The results showed that all synthesized compounds exhibited moderate antimicrobial activity, and compounds 2, 4, and 13 displayed cytotoxic activity (as LD50) at the concentration 1 × 10-3 M against Artemia salina.
Substituted heterocyclic compound containing acylhydrazone skeleton as well as preparation method and application thereof (by machine translation)
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, (2019/09/14)
The invention discloses a substituted heterocyclic compound containing an acylhydrazone skeleton as well as a preparation method and application, of the substituted heterocyclic compound. The invention relates to the field, in particular to a substituted heterocyclic compound containing an acylhydrazone skeleton or a pharmaceutically acceptable salt, a pharmaceutical composition containing the compounds and medical application, in particular to an FAAH inhibitor, and application, in preparation of drugs for preventing or treating diseases related to FAAH, including depression, analgesia, cannabinoid use disorders and other related diseases. (by machine translation)
About the Reactions of Benzimidazole-2-carbohydrazide with Electrophilic Compounds
Graubaum, Heinz,Martin, Dieter
, p. 515 - 521 (2007/10/02)
Benzimidazole-2-carbohydrazide (1) reacts with aldehydes and ketones to form N-alkylidene-benzimidazole-2-carbohydrazides (2a-j).With carbon disulfide, diphenyl carbonate and cyanates, ring closure takes plase to afford 1,2,4-triazines and 1,3,4-oxadiazoles.Attempts to synthesize 2-isocyanato-benzimidazole failed. 1H-n.m.r. and 13C-n.m.r. spectroscopic data of the compounds are given.
