108019-30-3

Upstream product

• 108246-15-7 (+/-)-4-Acetamino-1-phenyl-penten-⁽¹⁾-saeure-⁽⁵⁾ 
• 52161-73-6 2-acetylamino-2-(3-phenyl-propyl)malonic acid diethyl ester 
• 4392-24-9 Cinnamyl bromide 
• 101782-54-1 Acetamino-cinnamyl-malonsaeure-diethylester 
• 637-59-2 1-Bromo-3-phenylpropane 

Downstream Products

• 62777-26-8 D-N-acetyl-2-amino-5-phenylpentanoic acid 
• 34993-02-7 2-(R)-amino-5-phenylpentanoic acid 
• 36061-08-2 (2R)-2-amino-5-phenylpentanoic acid 
• 156130-68-6 2-(tert-butoxycarbonylamino)-5-phenyl-D-pentanoic acid 
• 416856-10-5 [1-(1-{[5-(4-chloro-phenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-1H-1λ⁶-isothiazol-4-ylmethyl]-ethyl-carbamoyl}-4-phenyl-butylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester 
• 206360-08-9 2-tert-butoxycarbonylamino-5-phenyl-pentanoic acid ethyl ester 
• 106270-07-9 2-methyl-4-(3-phenyl-propyl)-4H-oxazol-5-one 

Relevant academic research and scientific papers

Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues

A series of growth hormone secretagogues (GHSs) based on 2,3-dihydroisothiazole has been synthesized in the search for a potential treatment of growth hormone deficiency or frailty in the elderly. This paper describes the evaluation of the SAR of the benzyl-d-Ser-aminoisobutyric acid dipeptide fragment. Introduction of substituents in the peptide backbone and in the phenyl ring has been investigated, as well as replacements for the benzyl group and for the AIB residue. A number of modifications resulted in enhanced potency over the parent benzyl-d-Ser-AIB derivative.

Growth hormone secretagogues

What is disclosed are growth hormone secretagogues, and their uses, of the formula wherein R1 is C6H5CH2OCH2—, C6H5(CH2)3— or indol-3-ylmethyl; Y is pyrrolidin-1-yl, 4-C1-C6alkylpiperidin-1-yl or NR2R2; R2 are each independently a C1to C6alkyl; R3 is 2-napthyl or phenyl para-substituted by W; W is H, F, CF3, C1-C6alkoxy or phenyl; and R4 is H or CH3, or a pharmaceutically acceptable salt or solvate thereof.

STEREOSELECTIVE PROCESS FOR THE SYNTHESIS OF (D)-2-AMINO-5-PHENYLPENTANOIC OR ALKYL ESTER THEREOF

The present invention provides a process for preparing a compound of formula (I); wherein R is a C1-C6 alkyl; or a salt thereof; comprising:(c) hydrolyzing (D,L)-N-acetyl-2-amino-5-phenylpentanoic acid with a suitable base in the pre

Treatment of congestive heart failure with growth hormone secretagogues

The present invention is directed to methods for the modulation of cardiac function which comprise the administration of certain compounds, as defined herein, having growth hormone secretagogue activity.