62777-26-8

Upstream product

• 108019-30-3 DL-N-acetyl-2-amino-5-phenylpentanoic acid 
• 637-59-2 1-Bromo-3-phenylpropane 
• 52161-73-6 2-acetylamino-2-(3-phenyl-propyl)malonic acid diethyl ester 
• 62732-55-2 2-Acetylamino-2-(3-phenyl-propyl)-malonic acid 

Downstream Products

• 156130-68-6 2-(tert-butoxycarbonylamino)-5-phenyl-D-pentanoic acid 
• 416856-10-5 [1-(1-{[5-(4-chloro-phenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydro-1H-1λ⁶-isothiazol-4-ylmethyl]-ethyl-carbamoyl}-4-phenyl-butylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester 
• 206360-08-9 2-tert-butoxycarbonylamino-5-phenyl-pentanoic acid ethyl ester 

Relevant academic research and scientific papers

Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues

A series of growth hormone secretagogues (GHSs) based on 2,3-dihydroisothiazole has been synthesized in the search for a potential treatment of growth hormone deficiency or frailty in the elderly. This paper describes the evaluation of the SAR of the benzyl-d-Ser-aminoisobutyric acid dipeptide fragment. Introduction of substituents in the peptide backbone and in the phenyl ring has been investigated, as well as replacements for the benzyl group and for the AIB residue. A number of modifications resulted in enhanced potency over the parent benzyl-d-Ser-AIB derivative.

Growth hormone secretagogues

What is disclosed are growth hormone secretagogues, and their uses, of the formula wherein R1 is C6H5CH2OCH2—, C6H5(CH2)3— or indol-3-ylmethyl; Y is pyrrolidin-1-yl, 4-C1-C6alkylpiperidin-1-yl or NR2R2; R2 are each independently a C1to C6alkyl; R3 is 2-napthyl or phenyl para-substituted by W; W is H, F, CF3, C1-C6alkoxy or phenyl; and R4 is H or CH3, or a pharmaceutically acceptable salt or solvate thereof.