1080522-12-8

Basic information

• Product Name: 5-(2-methoxy-4-(2-methoxy-2-oxoethyl)phenoxy)-4-nitro-1H-indole-2-carboxylic acid
• Synonyms: 5-(2-methoxy-4-(2-methoxy-2-oxoethyl)phenoxy)-4-nitro-1H-indole-2-carboxylic acid
• CAS NO: 1080522-12-8
• Molecular Weight: 400.345
• Mol File: 1080522-12-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(2-methoxy-4-(2-methoxy-2-oxoethyl)phenoxy)-4-nitro-1H-indole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-methoxy-4-(2-methoxy-2-oxoethyl)phenoxy)-4-nitro-1H-indole-2-carboxylic acid(1080522-12-8)
• EPA Substance Registry System: 5-(2-methoxy-4-(2-methoxy-2-oxoethyl)phenoxy)-4-nitro-1H-indole-2-carboxylic acid(1080522-12-8)

Safety Data

• Hazardous Substances Data: 1080522-12-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 1080522-10-6 5-(4-(carboxymethyl)-2-methoxyphenoxy)-4-nitro-1H-indole-2-carboxylic acid 
• 1080522-09-3 ethyl 5-(4-(2-ethoxy-2-oxoethyl)-2-methoxyphenoxy)-4-nitro-1H-indole-2-carboxylate 
• 60563-13-5 ethyl homovanillate 
• 364-75-0 1-fluoro-4-iodo-2-nitro-benzene 
• 1080522-04-8 ethyl 2-(4-(4-iodo-2-nitrophenoxy)-3-methoxyphenyl)acetate 

Downstream Products

• 1080522-13-9 methyl 2-(4-(2-carbamoyl-4-nitro-1H-indol-5-yloxy)-3 methoxyphenyl)acetate 
• 1080521-11-4 2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid 
• 1080522-16-2 C₁₉H₁₉N₃O₅ 
• 1080522-18-4 C₂₅H₂₁Cl₂N₃O₇S 
• 1080522-19-5 methyl 2-(4-(2-cyano-4-(2,4-dichlorophenylsulfonamido)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate 

Relevant articles and documents

Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD2 receptors CRTH2 and DP

Based on their structural similarity to previously described compound AMG 009, indole-phenyl acetic acids were proposed to be potent dual inhibitors of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2 or DP2) and prostanoid D receptor (DP or DP1). This series was equipotent to AMG 009 in binding assays against both receptors but exhibited decreased serum shift. We discovered early in the optimization of these indole-phenylacetic acid compounds that they demonstrated CYP3A4 time-dependent inhibition (TDI). Hypothesizing that the source of TDI was the indole core we modified the 1,2,3-substitution to eventually afford a highly potent modulator of CRTH2 and DP which did not exhibit TDI.