1080573-21-2

Basic information

• Product Name: 4-acetoxymethyl-3-bromobenzoic acid methyl ester
• Synonyms: 4-acetoxymethyl-3-bromobenzoic acid methyl ester
• CAS NO: 1080573-21-2
• Molecular Weight: 287.11
• Mol File: 1080573-21-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-acetoxymethyl-3-bromobenzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-acetoxymethyl-3-bromobenzoic acid methyl ester(1080573-21-2)
• EPA Substance Registry System: 4-acetoxymethyl-3-bromobenzoic acid methyl ester(1080573-21-2)

Safety Data

• Hazardous Substances Data: 1080573-21-2(Hazardous Substances Data)

Upstream product

• 127-08-2 potassium acetate 
• 78946-25-5 3-bromo-4-(bromomethyl)benzoic acid methyl ester 
• 7697-26-9 3-bromo-4-methylbenzoic acid 
• 127-09-3 sodium acetate 
• 64-19-7 acetic acid 
• 104901-43-1 methyl 3-bromo-4-methylbenzoate 

Downstream Products

• 1221343-14-1 1-(hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)carboxylic acid 
• 90326-62-8 3-bromo-4-hydroxymethylbenzoic acid methyl ester 

Relevant articles and documents

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This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates. The diboron compounds are characterized by formula (I), which is: R1-X-R2, and wherein "X" is a mono- to multiatomic linker and where R1 and R2, which may be identical or different, each represents a group of Formula (lla) or (IIb) Also described are diboron conjugates represented by the general Formula (I'), which is: R1'-X'-R2', in which either the moeities R1' or R2' or X' carry a drug that is covalently attached to the diboron compound.

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A benzophenone derivative represented by the following formula: whereinR1 represents, for example, an optionally substituted heterocyclic group, or a substituted phenyl group; Z represents, for example, an alkylene group; R2 represents, for example, a carboxyl group optionally protected with alkyl;R3 represents, for example, an optionally protected hydroxyl group; R4 represents, for example, an optionally substituted cycloalkyloxy group; and R5 represents, for example, a hydrogen atom, ???or a salt thereof has anti-arthritic activity, inhibits bone destruction caused by arthritis, and provides high safety and excellent pharmacokinetics and thus is useful as therapeutic agent for arthritis. These compounds have inhibitory effect on AP-1 activity and are useful as preventive or therapeutic agent for diseases in which excessive expression of AP-1 is involved.