108059-83-2

Upstream product

• 67-56-1 methanol 
• 6512-83-0 2,2'-diselanediyl-di-benzoic acid 
• 104101-90-8 2-selenocyanato-benzoic acid 
• 36637-91-9 o-carbomethoxybenzeneselenenyl chloride 
• 108059-82-1 2-(Hydroseleno)benzoesaeure-methylester 
• 186581-53-3 diazomethane 
• 1441-85-6 2-(chloroseleno)benzoyl chloride 
• 1441-84-5 2-selenocyanato-benzoyl chloride 
• 78377-05-6 2-Selenocyanatobenzoesaeure-methylester 
• 118-92-3 anthranilic acid 
• 105893-07-0 2,2’-diselanediyldibenzoyl chloride 

Downstream Products

• 143716-05-6 methyl 2-(1,4-dimethoxy-2-naphthylseleno)benzoate 
• 143716-11-4 2-(1,4-Dimethoxy-naphthalen-2-ylselanyl)-benzoic acid 
• 143716-10-3 2-(1,4-Dihydroxy-naphthalen-2-ylselanyl)-benzoic acid methyl ester 
• 695196-43-1 2-(2,5-Dimethoxy-3,4-dimethyl-phenylselanyl)-benzoic acid 
• 143716-08-9 methyl 2-<(2,5-dimethoxy-3,4-dimethylphenyl)seleno>benzoate 
• 143716-12-5 2-(2,5-Dihydroxy-3,4-dimethyl-phenylselanyl)-benzoic acid methyl ester 

Relevant academic research and scientific papers

Glutathione S-transferase pi expression regulates the Nrf2-dependent response to hormetic diselenides

Glutathione S-transferase pi (GSTP), a phase II gene downstream of the nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant-responsive element (ARE)/electrophile response element (EpRE) transcription pathway, plays a key role in both the signali

Catalytic Oxidation of Alcohols to Carbonyl Compounds Mediated by N-(Arylseleno)-4-chlorobenzenesulfonamide

Most secondary alcohols and β,γ-unsaturated primary alcohols have been catalytically oxidized with N-chloro-4-chlorobenzenesulfonamide sodium salt to the corresponding carbonyl compounds by the addition of a 0.01-0.03 molar amount of dimethyl 2,2′-diselenodibenzoate in good-to-excellent yields, and a catalytic species, methyl 2-[N-(4-chlorophenylsulfonyl)aminoseleno]benzoate (8), was isolated from the reaction mixture. The catalytic oxidation cycle for this reaction is proposed; the decomposition of esters, which are produced by the reaction of alcohols with oxidized 8, was found to be the rate-determining step.

Dibenzocyclooctene-, Dibenzochalcocine-, and Diarenochalconinediones

2,2'-Oxybis-, -thiobis-, and -methylenebisbenzoic esters 2a-c react with methyllithium in ether to give low yields of 5H-dibenzochalcocine-5,7(6H)-diones 6a, 7a, and dibenzocyclooctene-5,7(6H,12H)-dione (8), respectively.Very good yields of such heterocycles with oxygen (6a-h, 37), sulfur (7a-h, 38) and selenium (36) as key atom are obtained when diaryl ethers (21, 22, 25), -sulfides (27, 29, 30), and -selenides (33) that contain 2'-acetyl- (or -propionyl-) and 2-methoxycarbonyl groups are treated with sodium hydride in boiling toluene.Analogously are prepared the dibenzoxonine-11,13(6H,12H)diones 62a-c and 7H-benzonaphthothionine-7,9-(8H)-dione (65) which are expanded by one ring member.In the analogous reaction of a corresponding benzophenone derivative 35, spiro-3(2H),3'-dione (41) is formed in a tandem reaction. - Under phase transfer conditions the dibenzochalcocinediones 6, 7, 36 and also the corresponding nitrogen cycles 5 react to give mixtures of C- (42-45) and O-alkyl derivatives (46-49).Methyllithium and diisobutylaluminium hydride provide the carbinols 50-54.With bromine and SO2Cl2, respectively, the methylene group is mono- or dihalogenated to the products 56, 57; defined nitration was only possible for the oxacycle 6a.