108138-16-5

Basic information

• Product Name: 3-Quinolinecarboxylic acid, 6,7-difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester
• CAS NO: 108138-16-5
• Molecular Formula: C18H12F3NO3
• Molecular Weight: 347.293
• Mol File: 108138-16-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarboxylic acid, 6,7-difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxylic acid, 6,7-difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester(108138-16-5)
• EPA Substance Registry System: 3-Quinolinecarboxylic acid, 6,7-difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-, ethyl ester(108138-16-5)

Safety Data

• Hazardous Substances Data: 108138-16-5(Hazardous Substances Data)

Upstream product

• 98349-24-7 ethyl 2,4,5-trifluorobenzoylacetate 
• 122-51-0 orthoformic acid triethyl ester 
• 62-53-3 aniline 
• 101799-75-1 α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester 
• 446-17-3 2,4,5-trifluorobenzoic acid 
• 108115-66-8 ethyl 3-(4-fuoroanilino)-2-(2,4,5-trifuorobenzoyl)acrylate 

Downstream Products

• 98106-17-3 difloxacin 
• 114676-86-7 (2'S,4'S)-7-(4'-amino-2'-methylpyrrolidinyl)-1-(p-fluorophenyl)-1,4-dihydro-6-fluoro-4-oxoquinoline-3-carboxylic acid hydrochloride 
• 98105-99-8 sarafloxacin 
• 103994-99-6 6,7-difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid 

Relevant articles and documents

Method for efficiently and environmentally friendly preparing quinolones

The invention discloses a method for efficiently and environmentally friendly preparing quinolones. Fluorobenzoylacetic acid ethyl ester, triethyl orthoformate and amine compounds are used as raw materials, and the quinolones are synthesized by maintainin

Effect of Lipophilicity at N-1 on Activity of Fluoroquinolones against Mycobacteria

The dramatic increase in drug resistant Mycobacterium tuberculosis has caused a resurgence in research targeted toward these organisms.As part of a systematic study to optimize the quinolone antibacterials against mycobacteria, we have prepared a series of N-1-phenyl-substituted derivatives to explore the effect of increasing lipophilicity on potency at this position.The compounds, synthesized by the modification of a literature procedure, were evaluated for activity against Gram-negative and Gram-positive bacteria, Mycobacterium fortuitum and Mycobacterium smegmatis, and the results correlated with log P, pKa, and other attributes.The activity of the compounds against the rapidly growing, less hazardous organism M. fortuitum was used as a measure of M. tuberculosis activity.The results demonstrate that increasing lipophilic character by itself does not correlate with increased potency against mycobacteria.Rather, intrinsic activity against Gram-negative and/or Gram-positive bacteria is the governing factor for corresponding activity against mycobacteria.

Heterocycylic-substituted quinoline-carboxylic acids

1-Substituted-6-fluoro-7-heterocyclic-1,4-dihydroquino-1-(or dihydronaphthyridin)-4-one carboxylic acids have antibacterial properties. The 7-heterocyclic group is a bicyclic group, one of the rings of which is saturated and the other ring of which is unsaturated.