103994-99-6

Basic information

• Product Name: 6,7-Difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid
• Synonyms: 6,7-Difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid
• CAS NO: 103994-99-6
• Molecular Formula: C₁₆H₈F₃NO₃
• Molecular Weight: 319.2348296
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 103994-99-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 258-260 °C(Solv: chloroform (67-66-3); ethanol (64-17-5))
• Boiling Point: 483.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.563±0.06 g/cm3(Predicted)
• PKA: 6.10±0.41(Predicted)
• CAS DataBase Reference: 6,7-Difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid(103994-99-6)
• EPA Substance Registry System: 6,7-Difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid(103994-99-6)

Safety Data

• Hazardous Substances Data: 103994-99-6(Hazardous Substances Data)

Usage

Uses

6,7-Difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid is an arylfluoroquinoline derivative used in the preparation of antibacterial agents.

Upstream product

• 108115-66-8 ethyl 3-(4-fuoroanilino)-2-(2,4,5-trifuorobenzoyl)acrylate 
• 98349-24-7 ethyl 2,4,5-trifluorobenzoylacetate 
• 446-17-3 2,4,5-trifluorobenzoic acid 
• 108138-16-5 1-(p-fluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl ester 

Downstream Products

• 138698-26-7 7-(1,4-Diaza-bicyclo[3.3.1]non-4-yl)-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 112894-29-8 1-(4-fluorophenyl)-6-fluoro-1,4-dihydro-7-(1,4-diazabicyclo[3.2.2]non-4-yl)-4-oxo-3-quinoline carboxylic acid 
• 98105-99-8 sarafloxacin 
• 108437-27-0 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7(8-methyl-3,8-diazabicyclo(3.2.1)oct-3-yl)-4-oxoquinoline-3-carboxylic acid 
• 138808-69-2 1-(4-Fluorophenyl)-6-fluoro-1,4-dihydro-7-{(1S_.4S)-2,5-diazabicyclo[2.2.1]hept-2-yl}-4-oxo-3-quinolinecarboxylic acid 
• 98106-17-3 difloxacin 
• 98106-29-7 6-Fluoro-1-(4-fluoro-phenyl)-7-morpholin-4-yl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 138698-14-3 6-Fluoro-1-(4-fluoro-phenyl)-7-(9-methyl-3,9-diaza-bicyclo[4.2.1]non-3-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 138808-75-0 6-Fluoro-1-(4-fluoro-phenyl)-7-((1S,4S)-5-methyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 123187-96-2 1-(4-fluorophenyl)-6-fluoro-7-<3-(fluoromethyl)-1-piperazinyl>-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 

Relevant articles and documents

Synthesis of norfloxacin analogues catalyzed by Lewis and Br?nsted acids: An alternative pathway

An alternative synthetic pathway to prepare norfloxacin analogues is presented. Three Lewis acids (CeCl3·7H2O, AlCl 3·6H2O, ZnCl2) and one Bro?nsted acid (TsOH) were tested as catalysts in the prepara

Baylis-Hillman route to several quinolone antibiotic intermediates

Treatment of methyl propiolate and 2,4,5-trifluoro-, 2-fluoro-, 2-fluoro-5-methoxy- or 2,3,4,5-tetrafluorobenzaldehydes with a ZrCl 4/Bu4NI combination induces an aldol reaction to furnish β-iodo-α-(hydroxyalkyl)acrylates. These can be used for the preparation of several quinolone intermediates, 1-substituted 4-oxo-1,4-dihydroquinoline-3-carboxylic acids and 9,10-difluoro-3-methyl-2,3- dihydro-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid through the oxidation, amination and hydrolysis reactions. Georg Thieme Verlag Stuttgart.

Heterocycylic-substituted quinoline-carboxylic acids

1-Substituted-6-fluoro-7-heterocyclic-1,4-dihydroquino-1-(or dihydronaphthyridin)-4-one carboxylic acids have antibacterial properties. The 7-heterocyclic group is a bicyclic group, one of the rings of which is saturated and the other ring of which is unsaturated.