108206-05-9

Basic information

• Product Name: 2-[(ethylamino)methyl]phenol
• Synonyms: 2-[(ethylamino)methyl]phenol
• CAS NO: 108206-05-9
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.20562
• Mol File: 108206-05-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 246.0±15.0 °C(Predicted)
• Appearance: /
• Density: 1.035±0.06 g/cm3(Predicted)
• PKA: 9.25±0.30(Predicted)
• CAS DataBase Reference: 2-[(ethylamino)methyl]phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(ethylamino)methyl]phenol(108206-05-9)
• EPA Substance Registry System: 2-[(ethylamino)methyl]phenol(108206-05-9)

Safety Data

• Hazardous Substances Data: 108206-05-9(Hazardous Substances Data)

Usage

General Description

2-[(ethylamino)methyl]phenol, also known as N-(2-hydroxyethyl)-N-ethylbenzenemethanamine, is a chemical compound with the molecular formula C10H15NO. It is an organic compound that consists of a phenol group substituted with an ethylaminoethyl group. This chemical can be used as a building block in organic synthesis and as a raw material in the production of pharmaceuticals and agrochemicals. Additionally, it has been identified as a potential intermediate in the synthesis of novel bioactive molecules. Due to its structural properties and potential applications, 2-[(ethylamino)methyl]phenol is a compound of interest in both research and industrial settings.

Upstream product

• 5961-36-4 H-Sal-N-Et 
• 90-02-8 salicylaldehyde 
• 75-04-7 ethylamine 
• 932-30-9 2-Hydroxybenzylamine 

Relevant articles and documents

Novel nonquaternary reactivators showing reactivation efficiency for soman-inhibited human acetylcholinesterase

Soman is a highly toxic nerve agent with strong inhibition of acetylcholinesterase (AChE), but of the few reactivators showing antidotal efficiency for soman-inhibited AChE presently are all permanently charged cationic oximes with poor penetration of the blood-brain barrier. To overcome this problem, uncharged reactivators have been designed and synthesized, but few of them were efficient for treating soman poisoning. Herein, we used a dual site biding strategy to develop more efficient uncharged reactivators. The ortho-hydroxylbenzaldoximes were chosen as reactivation ligands of AChE to prevent the secondary poisoning of AChE, and simple aromatic groups were used as peripheral site ligands of AChE, which were linked to the oximes in a similar way as that found in the reactivator HI-6. The in vitro experiment demonstrated that some of the resulting conjugates have robust activity against soman-inhibited AChE, and oxime 8b was highlighted as the most efficient one. Although not good as HI-6 in vitro, these new compounds hold promise for development of more efficient centrally acting reactivators for soman poisoning due to their novel nonquaternary structures, which are predicted to be able to cross the blood-brain barrier.

Selective mono-N-alkylation of 3-amino alcohols via chelation to 9-BBN

(Chemical Equation Presented) A method for selective mono-N-alkylation of amino alcohols is introduced. This method relies on formation of a stable chelate with 9-BBN, which serves in the dual roles of protecting and activating the amine group. Three prot

Central cholinergic agents. I. Potent acetylcholinesterase inhibitors, 2-[ω-[N-alkyl-N-(ω-phenylalkyl)amino]alkyl]-1H-isoindole-1,3(2H)-dion es, based on a new hypothesis of the enzyme's active site

It has been suggested that the active site of acetylcholinesterase contains a hydrophobic binding site (HBS-1), which is closely adjacent to both the anionic and the esteratic sites. In this paper, we assumed that there exists another hydrophobic binding site (HBS-2), some distance removed from the anionic site. On this assumption, a new working hypothesis was proposed for the design of acetylcholinesterase inhibitors. A series of 2-[ω-[N-alkyl-N-(ω-phenylalkyl)amino]alkyl]-1H-isoindole-1,3(2H)-dion es was designed based on this hypothesis and tested for its inhibitory activities on acetylcholinesterase. Some in this series were revealed to be more potent than physostigmine. Optimum activity was found to be associated with a five carbon chain length separating the benzylamino group from the 1H-isoindole-1,3(2H)-dione (phthalimide) moiety. Quantitative study of substitution effect on the phthalimide moiety revealed that hydrophilic and electron-withdrawing groups enhance the activity.