5961-36-4

Upstream product

• 90-02-8 salicylaldehyde 
• 75-04-7 ethylamine 
• 557-66-4 ethanamine hydrochloride 

Downstream Products

• 3359-49-7 3-benzylideneoxindole 
• 26194-23-0 {Cu(C₆H₄(O)CHNCH₂CH₃)2} 
• 14096-19-6 bis(N-ethylsalicylaldiminato)copper(II) 
• 82056-86-8 MoOCl₃(OHC₆H₄CHNCH₂CH₃)2 
• 715-56-0 (2-hydroxy-1-naphthylmethylene)ethylamine 

Relevant academic research and scientific papers

Novel nonquaternary reactivators showing reactivation efficiency for soman-inhibited human acetylcholinesterase

Soman is a highly toxic nerve agent with strong inhibition of acetylcholinesterase (AChE), but of the few reactivators showing antidotal efficiency for soman-inhibited AChE presently are all permanently charged cationic oximes with poor penetration of the blood-brain barrier. To overcome this problem, uncharged reactivators have been designed and synthesized, but few of them were efficient for treating soman poisoning. Herein, we used a dual site biding strategy to develop more efficient uncharged reactivators. The ortho-hydroxylbenzaldoximes were chosen as reactivation ligands of AChE to prevent the secondary poisoning of AChE, and simple aromatic groups were used as peripheral site ligands of AChE, which were linked to the oximes in a similar way as that found in the reactivator HI-6. The in vitro experiment demonstrated that some of the resulting conjugates have robust activity against soman-inhibited AChE, and oxime 8b was highlighted as the most efficient one. Although not good as HI-6 in vitro, these new compounds hold promise for development of more efficient centrally acting reactivators for soman poisoning due to their novel nonquaternary structures, which are predicted to be able to cross the blood-brain barrier.

Functionalized Salen ligands linking with non-conjugated bridges: unique and colorful aggregation-induced emission, mechanism, and applications

A series of novel, simple, and colorful Salen ligands (56 samples), salicylaldehyde-based bis-Schiff bases, linking with different non-conjugated alkyl bridges ((CH2)n, n = 2-9, 12; cyclohexyl) and containing different electron-accepting (-NO2, -F, and -Cl), electron-donating (-OMe, -OH, and -NEt2), or sterically hindering (-t-butyl) substituents or a π-extended system (naphthalene ring) have been designed and synthesized. The photophysical properties of these Salen ligands can be well-tuned by the introduction of side functional substituents, π-extended systems, and central N-alkyl chain bridges. It is unusual that they contain a small π-conjugated system but display strong blue, green, and red aggregation-induced emission (AIE) with large Stokes shifts (up to 162 nm) and high fluorescence quantum yields (up to 0.44 and 0.75 in water and in solid, respectively). Combining with their advantages of AIE and good stability and biocompatibility, the Salen ligands can be potentially used in mechanofluorochromism (crystal-defect-induced emission) and living cell imaging. Moreover, the inherent relationships between their chemical structures and AIE properties are studied, which provide unequivocal insights for the design of AIE-active dyes.

Preparation of nanostructured materials through thermolysis of metal chelate complexes

We demonstrate that nanocomposites (metals and metal carbides and sulfides) can be produced by thermolysis (370 and 600°C) in a self-generated atmosphere using Cu(II), Co(II), and Ni(II) 2-hydroxy- and 2-N- tosylaminobenzaldehyde azomethine bis-chelates a

Synthesis and Bleaching Activity of 1,5-Disubstituted Imidazoles

A variety of 1,5-disubstituted imidazoles and related compounds were prepared, and their bleaching activity was evaluated by using the lettuce seedling test. 5-(4-Benzyloxyphenyl)-1-ethylimidazole (13) caused clear chlorosis, while the 2- and 3-benzyloxyp

Central cholinergic agents. I. Potent acetylcholinesterase inhibitors, 2-[ω-[N-alkyl-N-(ω-phenylalkyl)amino]alkyl]-1H-isoindole-1,3(2H)-dion es, based on a new hypothesis of the enzyme's active site

It has been suggested that the active site of acetylcholinesterase contains a hydrophobic binding site (HBS-1), which is closely adjacent to both the anionic and the esteratic sites. In this paper, we assumed that there exists another hydrophobic binding site (HBS-2), some distance removed from the anionic site. On this assumption, a new working hypothesis was proposed for the design of acetylcholinesterase inhibitors. A series of 2-[ω-[N-alkyl-N-(ω-phenylalkyl)amino]alkyl]-1H-isoindole-1,3(2H)-dion es was designed based on this hypothesis and tested for its inhibitory activities on acetylcholinesterase. Some in this series were revealed to be more potent than physostigmine. Optimum activity was found to be associated with a five carbon chain length separating the benzylamino group from the 1H-isoindole-1,3(2H)-dione (phthalimide) moiety. Quantitative study of substitution effect on the phthalimide moiety revealed that hydrophilic and electron-withdrawing groups enhance the activity.

X-Ray Structures of Several Bis(N-alkylsalicylaldiminato)zinc(II) Complexes

X-Ray structures of five bis(N-R-salicylaldiminato)zinc(II) complexes with R = ethyl, n-propyl, i-propyl, n-butyl and 4-thia-n-hexyl were determined.The N2O2 coordination geometry is in all cases quasi-tetrahedral with the dihedral angle between the plane

N-Substituted Salicylaldimines Derivatives of Germanium(IV)

Hexa-coordinated Schiff base complexes of germanium of the general type Ge(OC2H5)2(SB)2 (SB(-) is the anion of the monofunctional bidentate Schiff base, SBH) have been synthesized by the reaction between ethyl-orthogermanate and the Schiff base in benzene