1082071-89-3Relevant articles and documents
Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold
Marsilje, Thomas H.,Alper, Phil B.,Lu, Wenshuo,Mutnick, Daniel,Michellys, Pierre-Yves,He, Yun,Karanewsky, Donald S.,Chow, Donald,Gerken, Andrea,Lao, Jianmin,Kim, Min-Ju,Seidel, H. Martin,Tian, Shin-Shay
scheme or table, p. 5259 - 5262 (2009/05/07)
The lead optimization of a novel series of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor is reported. The chemical instability of the dihydro-benzo[a]carbazole lead 2 was successfully addressed in the design and eval