108213-17-8

Basic information

• Product Name: Ethanol, 2-[2-(2-chloroethoxy)ethoxy]-, 4-methylbenzenesulfonate
• CAS NO: 108213-17-8
• Molecular Formula: C13H19ClO5S
• Molecular Weight: 322.81
• Mol File: 108213-17-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Ethanol, 2-[2-(2-chloroethoxy)ethoxy]-, 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-[2-(2-chloroethoxy)ethoxy]-, 4-methylbenzenesulfonate(108213-17-8)
• EPA Substance Registry System: Ethanol, 2-[2-(2-chloroethoxy)ethoxy]-, 4-methylbenzenesulfonate(108213-17-8)

Safety Data

• Hazardous Substances Data: 108213-17-8(Hazardous Substances Data)

Usage

General Description

2-[2-(2-chloroethoxy)ethoxy]-ethanol, 4-methylbenzenesulfonate, commonly known as Methyl 2-(2-(2-chloroethoxy)ethoxy)ethanol, is a chemical compound with the formula C11H15ClO4S. It is a white to off-white crystalline powder that is soluble in water and organic solvents. Ethanol, 2-[2-(2-chloroethoxy)ethoxy]-, 4-methylbenzenesulfonate is commonly used as a solvent in industrial applications, as well as in the synthesis of various pharmaceuticals and agrochemicals. It may also be used as a dispersant, emulsifier, or wetting agent in different formulations. Additionally, it is known to have skin and eye irritant properties and should be handled with care in a laboratory or industrial setting.

Upstream product

• 5197-62-6 2-[2-(chloroethoxy)ethoxy]ethanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 112-26-5 1,2-bis(2-chloroethoxy)ethane 
• 926894-27-1 C₃₉H₄₃ClO₇ 
• 1445733-76-5 1,4-bis(2-(2-(2-chloroethoxy)ethoxy)ethoxy)-2,5-diiodobenzene 
• 1445733-77-6 tert-butyl 2,2'2'',2'''-[2,2'-(2,2'-[2,2'-(2,5-diiodo-1,4-phenylene)bis(oxy)bis(ethane-2,1-diyl)]bis(oxy)bis(ethane-2,1-diyl))bis(oxy)bis(ethane-2,1-diyl)]bis(azanetriyl)tetrakis(ethane-2,1-diyl)tetracarbamate 
• 143602-19-1 1,10,19,28-tetratosyl-4,7,13,16,22,25,31,34-octaoxa-1,10,19,28-tetraazacycyclohexatriacontane 
• 143602-20-4 7,14,23,30-Tetrakis-(toluene-4-sulfonyl)-1,4,17,20-tetraoxa-7,14,23,30-tetraaza-cyclodotriacontane 
• 268746-66-3 C₅₃H₆₅NO₁₀S 
• 88037-69-8 1,2-Bis-{2-[2-(2-chloro-ethoxy)-ethoxy]-ethoxy}-benzene 

Relevant articles and documents

New multi(tetrathiafulvalene) dendrimers

The convergent synthesis of multi(TTF) dendrimers with glycol chains as the branches is reported. Key methodology in the iterative steps involves nucleophilic displacement of reactive halides by transient TTF-thiolate anions. Core units in the dendrimers

Selective degradation of CDK6 by a palbociclib based PROTAC

Development of selective kinase inhibitors that target the ATP binding site continues to be a challenge largely due to similar binding pockets. Palbociclib is a cyclin-dependent kinase inhibitor that targets the ATP binding site of CDK4 and CDK6 with similar potency. The enzymatic function associated with the kinase can be effectively probed using kinase inhibitors however the kinase-independent functions cannot. Herein, we report a palbociclib based PROTAC that selectively degrades CDK6 while sparing the homolog CDK4. We used competition studies to characterize the binding and mechanism of CDK6 degradation.

Practical use of NH4X salts for difunctional oxyethylene-based intermediates

A series of tosyl functionalized oxyethylene-based organic compounds were selected to analyze the scope and efficiency of a general substitution method for conversion to difunctional, soluble oxyethylene based intermediates using readily available ammonium salts, glycols and commercially modified ethoxy-ethanols. Straightforward preparation, product purification and low cost reagents are particularly advantageous for compounds incorporating halides, thiocyanates and methoxy groups.