108227-57-2

Upstream product

• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 2450-71-7 Propargylamine 

Downstream Products

• 1198357-11-7 C₁₈H₁₆Cl₂N₂O₄S₂ 
• 1393746-03-6 C₂₇H₃₀ClF₂N₅O₁₁S 
• 1201227-66-8 C₂₂H₂₄Cl₂FN₅O₄S 
• 1201227-62-4 C₂₃H₂₆Cl₂FN₅O₄S 

Relevant academic research and scientific papers

Fluorocyclization of Allyl Alcohols and Amines to Access 3-Functionalized Oxetanes and Azetidines

An efficient method to prepare 3-functionalized oxetanes and azetidines has been realized by fluorocyclization of readily available 2-azidoallyl/2-alkoxyallyl alcohols and amines. Notably, this is the first example applying the fluorocyclization strategy to construct four-membered heterocycles. The pendant electron-donating group (-N3 or -OR) plays a crucial role in polarizing the C= C double bond and facilitating the cyclization process, as verified by DFT and experimental studies.

Synthesis, in?vitro anticancer and antibacterial activities and in silico studies of new 4-substituted 1,2,3-triazole–coumarin hybrids

The 4-substituted 1,2,3-triazole core in designed coumarin hybrids (4–35) with diverse physicochemical properties was introduced by eco-friendly copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition under microwave irradiation. Coumarin–1,2,3-triazole–ben

Structure optimization and bioactivity evaluation of ThDP analogs targeting cyanobacterial pyruvate dehydrogenase E1

Harmful cyanobacteria bloom (HCB) has occurred frequently in recent years and it is urgent to develop novel algicides to deal with this problem. In this paper, a series of novel thiamin diphosphate (ThDP) analogs 5a?5g were designed and synthesized target

Ruthenium Carbene-Mediated Construction of Strained Allenes via the Enyne Cross-Metathesis/Cyclopropanation of 1,6-Enynes

Herein, we report on the unprecedented dimerization of 1,6-enynes using a commercially available ruthenium complex RuCl2(PPh3)3, which results in a series of bicyclo[3.1.0]hexyl allene derivatives in moderate to excellent yields. Mechanistic investigation indicates that the in-situ-generated ruthenium vinylidene undergoes a site-selective metathesis process to provide allenyl ruthenium carbene, which can be intramolecularly trapped by the pendent C=C bond of enyne through a [2 + 2] cycloaddition/metal elimination process.

Orthogonal Syntheses of 3.2.0 Bicycles from Enallenes Promoted by Visible Light

Enallenes can be readily converted into two families of 3.2.0 (hetero)bicycles with high diastereoselectivities through the combination of visible light with a suitable Ir(III) complex (1 mol percent). Two complementary pathways, namely, a photocycloaddit

Design, synthesis, biological evaluation and molecular docking of amide and sulfamide derivatives as Escherichia coli pyruvate dehydrogenase complex E1 inhibitors

In this study, a series of novel amide derivatives and sulfamide derivatives as potential E. coli PDHc E1 inhibitors were designed and synthesized by optimizing the linker between triazole and benzene ring moieties based on the structure of lead compound

Synthesis of trisubstituted pyrroles from rhodium-catalyzed alkyne head-to-tail dimerization and subsequent goldcatalyzed cyclization

Dimerization of N-protected propargylic amines in a rather rare head-to-tail mode has been achieved under mild conditions with high selectivity using rhodium catalysts. The JV-protecting group could be a sulfonyl, carbamate, or carbonyl functionality and