1082429-86-4

Basic information

• Product Name: 2-chloro-3-(4-fluorophenyl)-1,8-naphthyridine
• Synonyms: 2-chloro-3-(4-fluorophenyl)-1,8-naphthyridine
• CAS NO: 1082429-86-4
• Molecular Weight: 258.682
• Mol File: 1082429-86-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-chloro-3-(4-fluorophenyl)-1,8-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-3-(4-fluorophenyl)-1,8-naphthyridine(1082429-86-4)
• EPA Substance Registry System: 2-chloro-3-(4-fluorophenyl)-1,8-naphthyridine(1082429-86-4)

Safety Data

• Hazardous Substances Data: 1082429-86-4(Hazardous Substances Data)

Upstream product

• 60467-61-0 2-amino-3-(4-fluorophenyl)-1,8-naphthyridine 
• 459-22-3 4-fluorophenylacetonitrile 
• 1082429-76-2 1,2-dihydro-3-(4-fluorophenyl)-1,8-naphthyridin-2-one 
• 7521-41-7 2-Aminonicotinaldehyde 

Downstream Products

• 1153668-78-0 2-hydrazino-3-(4-fluorophenyl)-1,8-naphthyridine 
• 1345691-28-2 C₂₁H₁₅FN₄ 
• 1345691-29-3 C₂₂H₁₇FN₄ 
• 1345691-30-6 C₂₂H₁₇FN₄O 
• 1345691-31-7 C₂₁H₁₄ClFN₄ 
• 1345691-32-8 C₂₁H₁₄ClFN₄ 
• 1345691-33-9 C₂₁H₁₄FN₅O₂ 
• 1345691-34-0 C₂₁H₁₄FN₅O₂ 
• 1345691-35-1 C₂₃H₁₉FN₄O₂ 
• 1345691-36-2 C₂₁H₁₃FN₄ 
• 1345691-37-3 C₂₂H₁₅FN₄ 
• 1345691-38-4 C₂₂H₁₅FN₄O 
• 1345691-39-5 C₂₁H₁₂ClFN₄ 
• 1345691-40-8 C₂₁H₁₂ClFN₄ 

Relevant articles and documents

A Simple “Green” Synthesis of Novel Bis(3-aryl-1,8-naphthyridin-2-yl)sulfanes and 2-(Methylthio)-3-aryl-1,8-naphthyridines under Microwave Irradiation and Conventional Conditions

An eco-friendly and highly efficient synthesis of substituted bis(3-aryl-1,8-naphthyridin-2-yl)-sulfanes and 2-(methylthio)-3-aryl-1,8-naphthyridines under microwave and conventional conditions. The products are obtained with high yields and purity within short reaction time. The synthesized derivatives are screened for anti-microbial activity against bacteria and fungi. Molecular docking of the synthesized compounds with DNA Gyrase is studied.

Green synthesis of 1,2,4-triazolo[4,3-a][1,8]naphthyridines using PhI(OAc)2-Al2O3 under microwave irradiation

Alumina-supported iodobenzene diacetate [PhI(OAc)2-Al 2O3] is a highly efficient reagent for the oxidative cyclization of N-arylidene-N′-[3-(4-fluorophenyl)-[1,8]naphthyridin-2-yl]- hy-drazines 7 to 1-aryl-4-[4-fluoro phenyl]-1,2,4-triazolo[4,3-a][1,8] naphthyridines 8 in solvent-free conditions under microwave irradiation. The products are obtained in good yields and excellent purities. The structural assignments of compounds 3-8 were based on their spectral (IR, 1H NMR and MS) and analytical data.