108261-07-0

Basic information

• Product Name: 8-Methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinolin-4-ol
• Synonyms: 5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-8-ol;8-Methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinolin-4-ol;4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-8-ol
• CAS NO: 108261-07-0
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237.25
• Mol File: 108261-07-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-Methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinolin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinolin-4-ol(108261-07-0)
• EPA Substance Registry System: 8-Methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinolin-4-ol(108261-07-0)

Safety Data

• Hazardous Substances Data: 108261-07-0(Hazardous Substances Data)

Usage

Uses

5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-8-ol is an intermediate in the synthesis of Cotarnine Chloride (C717500), an oxidative degradation product of the drug Noscapine (N882000).

Upstream product

• 108261-02-5 -N-methylamino>acetaldehyde dimethyl acetal 
• 108261-01-4 -N-methylamino>acetaldehyde diethyl acetal 
• 59259-90-4 5-(dimethoxymethyl)benzo[d][1,3]dioxole 
• 128580-99-4 4-Methoxy-5-(2',2'-dimethoxyethyl)carbimino-1,3-benzodioxolan 
• 108460-85-1 amino>acetaldehyde dimethyl acetal 
• 108261-03-6 N-(2-methoxy-3,4-methylenedioxybenzyl)-N-(p-toluene-sulfonyl)aminoacetaldehyde diethylacetal 
• 108261-05-8 N-(2-methoxy-3,4-methylenedioxybenzyl)-p-toluenesulfonamide 
• 108261-00-3 amino>acetaldehyde diethyl acetal 
• 137115-13-0 N-(3,4-methylenedioxybenzyl)-N-methyl-2,2-diethoxyethylamine 
• 5779-99-7 4-methoxybenzo[d][1,3]dioxole-5-carbaldehyde 
• 120-57-0 piperonal 
• 50-00-0 formaldehyd 
• 127063-97-2 5,6,7,8-Tetrahydro-4-methoxy-1,3-dioxolo<4,5-g>isoquinolin-8-ol 

Downstream Products

• 108434-83-9 2,3-dihydro-8-methoxy-2-methyl-6,7-methylenedioxy-4(1H)-isoquinolone 
• 128-62-1 (±)-α-noscapine 
• 30936-27-7 4-methoxy-6-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium iodide 
• 82-54-2 4-methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-ol 
• 550-10-7 hydrocotarnine 
• 108434-79-3 5,6,7,8-Tetrahydro-8-acetoxy-4-methoxy-6-methyl-1,3-dioxolo<4,5-g>isoquinoline 

Relevant articles and documents

A new total synthesis of (±)-α-noscapine

A new, convergent total synthesis of (±)-α-noscapine was developed on a grams scale through the condensation of 3-trimethylsilyl-meconin derivative 9 and the iodized salt cotarnine derivative 20 as the key step. Staring from simple 2,3-dimethoxybenzoic acid, piperonal and 2,2-dimethoxyethanamine, through the traditional chemical processes to give the final product in 11.6% yield over 14 steps.

AN EASY AND VERSATILE ACCESS TO 8-SUBSTITUTED ISOQUINOLINES

Lithiation of N-(2,2-diethoxyethyl)benzylamines and subsequent reaction with electrophiles allow to introduce a variety of carbo- and heterofunctional groups in the ortho-position.Subsequent acid-catalyzed cyclization leads to isoquinolines having an unco

Benzylamine derivative

There is provided a novel benzylamine derivative of the formula I: STR1 wherein R1 represents a hydrogen atom or a methyl group, X represents a hydrogen atom, a methyl group or a tosyl group, and Y represents a hydrogen atom, a methyl group or STR2 in which R2 and R3 being identical or different from each other represent independently a lower alkyl group.