108274-33-5

Usage

Uses

Used in Pharmaceutical Industry:
5-(bromomethyl)-2-(trifluoromethyl)pyridine is used as a synthetic intermediate for the preparation of aryl piperidines and piperazines. These compounds serve as inducers of LDL-receptor expression, which can be beneficial in the treatment of conditions related to lipid metabolism and cardiovascular health.
Used in Chemical Synthesis:
In the field of chemical synthesis, 5-(bromomethyl)-2-(trifluoromethyl)pyridine is utilized as a building block for the creation of more complex molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science. Its unique structural features allow for a wide range of reactions and modifications, making it a versatile component in the development of new compounds with specific properties and functions.

InChI:InChI=1/C7H5BrF3N/c8-3-5-1-2-6(12-4-5)7(9,10)11/h1-2,4H,3H2

Upstream product

• 231291-22-8 6-trifluoromethylnicotinic acid 
• 386704-04-7 6-(trifluoromethyl)pyridin-3-ylmethanol 
• 386704-12-7 6-(trifluoromethyl)pyridine-3-carbaldehyde 

Downstream Products

• 1029044-16-3 5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine 
• 1361968-59-3 1-(2-fluoro-4-((6-(trifluoromethyl)pyridin-3-yl)methyl)phenyl)propan-1-one 
• 1361968-49-1 1-(2-fluoro-4-((6-(trifluoromethyl)pyridin-3-yl)methyl)phenyl)propan-1-ol 
• 1361967-55-6 2-(2-fluoro-4-((6-(trifluoromethyl)pyridin-3-yl)methyl)phenyl)-3-methylquinolin-4(1H)-one 

Relevant academic research and scientific papers

Discovery of Orally Bioavailable and Liver-Targeted Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PHD) Inhibitors for the Treatment of Anemia

We report herein the design and synthesis of a series of orally active, liver-targeted hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitors for the treatment of anemia. In order to mitigate the concerns for potential systemic side effects, we

IMIDAZOLIDINONE DERIVATIVES AS INHIBITORS OF PERK

The invention is directed to substituted imidazolidinone derivatives. Specifically, the invention is directed to compounds according to Formula I (I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y1, Y2 and Z are defined herein. The compounds of the invention are inhibitors of PERK and can be useful in the treatment of cancer, pre-cancerous syndromes, as Alzheimer's disease, neuropathic pain, spinal cord injury, traumatic brain injury, ischemic stroke, stroke, Parkinson disease, diabetes, metabolic syndrome, metabolic disorders, Huntington's disease, Creutzfeldt-Jakob Disease, fatal familial insomnia, Gerstmann-Str?ussler-Scheinker syndrome, and related prion diseases, amyotrophic lateral sclerosis, progressive supranuclear palsy, myocardial infarction, cardiovascular disease, inflammation, organ fibrosis, chronic and acute diseases of the liver, fatty liver disease, liver steatosis, liver fibrosis, chronic and acute diseases of the lung, lung fibrosis, chronic and acute diseases of the kidney, kidney fibrosis, chronic traumatic encephalopathy (CTE), neurodegeneration, dementias, frontotemporal dementias, tauopathies, Pick's disease, Neimann-Pick's disease, amyloidosis, cognitive impairment, atherosclerosis, ocular diseases, arrhythmias, in organ transplantation and in the transportation of organs for transplantation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Nitromethylene derivatives and their use as insecticides

The present invention provides novel nitromethylene derivatives of the formula (I) STR1 wherein R represents a hydrogen atom or an alkyl group, X represents a haloalkyl, haloalkoxy, haloalkylthio, haloalkylsulfinyl, haloalkylsulfonyl, nitro, cyano, thiocyanato, haloalkenyl, haloalkynyl, hydroxyl, alkoxycarbonyl, amino, acyl, dialkylamino, acylamino or alkoxy group, l represents 1, 2 or 3 provided that when l is 1, X does not represent an alkoxy group and when l is 2 or 3, not all substituents X represent an alkoxy group, m represents 2, 3 or 4, and n represents 0 or 1, and the use of the new compounds as insecticides.