108296-59-9Relevant academic research and scientific papers
1,2-Amino Alcohols via Cr/Photoredox Dual-Catalyzed Addition of α-Amino Carbanion Equivalents to Carbonyls
Schwarz, J. Luca,Kleinmans, Roman,Paulisch, Tiffany O.,Glorius, Frank
, p. 2168 - 2174 (2020/03/03)
Herein, we report the synthesis of protected 1,2-amino alcohols starting from carbonyl compounds and α-silyl amines. The reaction is enabled by a Cr/photoredox dual catalytic system that allows the in situ generation of α-amino carbanion equivalents which act as nucleophiles. The unique nature of this reaction was demonstrated through the aminoalkylation of ketones and an acyl silane, classes of electrophiles that were previously unreactive toward addition of alkyl-Cr reagents. Overall, this reaction broadens the scope of Cr-mediated carbonyl alkylations and discloses an underexplored retrosynthetic strategy for the synthesis of 1,2-amino alcohols.
Silyl-Substituted Cyanoamines as Reagents for Heterocyclic Synthesis
Padwa, Albert,Eisenbarth, Philipp,Venkatramanan, M. K.,Wong, Geoerge, S. K.
, p. 2427 - 2432 (2007/10/02)
Attempts to silylate the anion derived from several (dialkylamino)acetonitriles with chlorotrimethylsilane gave self-condensation products.Slow addition of chlorotrimethylsilane to (benzylmethylamino)acetonitrile followed by treatment of the resulting amm
