123701-29-1

Upstream product

• 74-83-9 methyl bromide 
• 108296-59-9 2-(benzyl(methyl)amino)-2-(trimethylsilyl)acetonitrile 
• 75-16-1 methylmagnesium bromide 
• 103-67-3 benzyl-methyl-amine 

Downstream Products

• 123701-35-9 Benzyl-ethyl-methyl-(1-trimethylsilanyl-ethyl)-ammonium; iodide 
• 123701-34-8 N-benzyl-N,N-dimethyl-1-(trimethylsilyl)ethylammonium iodide 

Relevant academic research and scientific papers

1,2-Amino Alcohols via Cr/Photoredox Dual-Catalyzed Addition of α-Amino Carbanion Equivalents to Carbonyls

Herein, we report the synthesis of protected 1,2-amino alcohols starting from carbonyl compounds and α-silyl amines. The reaction is enabled by a Cr/photoredox dual catalytic system that allows the in situ generation of α-amino carbanion equivalents which act as nucleophiles. The unique nature of this reaction was demonstrated through the aminoalkylation of ketones and an acyl silane, classes of electrophiles that were previously unreactive toward addition of alkyl-Cr reagents. Overall, this reaction broadens the scope of Cr-mediated carbonyl alkylations and discloses an underexplored retrosynthetic strategy for the synthesis of 1,2-amino alcohols.

Synthesis of 1-(Trimethylsilyl)alkylamines

Several N,N-dialkylamines 4 were synthesized by the reaction of a Grignard reagent with 2-dialkylamino-2-(trimethylsilyl)acetonitriles 3 prepared by silylation of (dialkylamino)acetonitriles 1.