1083057-13-9

Basic information

• Product Name: 2-(3-(tert-butoxycarbonyl)phenyl)-3-Methylpyridin-1-iuM hydroxide
• Synonyms: 2-(3-(tert-butoxycarbonyl)phenyl)-3-Methylpyridin-1-iuM hydroxide;2-(3-(tert-butoxycarbonyI)phenyl)-3-methylpyridine-1-oxide;XCUIBTMCQYIOHJ-UHFFFAOYSA-N
• CAS NO: 1083057-13-9
• Molecular Formula: C₁₇H₁₉NO₃
• Molecular Weight: 287.35354
• Mol File: 1083057-13-9.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 472.7±33.0 °C(Predicted)
• Appearance: /
• Density: 1.08±0.1 g/cm3(Predicted)
• PKA: 0.76±0.10(Predicted)
• CAS DataBase Reference: 2-(3-(tert-butoxycarbonyl)phenyl)-3-Methylpyridin-1-iuM hydroxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-(tert-butoxycarbonyl)phenyl)-3-Methylpyridin-1-iuM hydroxide(1083057-13-9)
• EPA Substance Registry System: 2-(3-(tert-butoxycarbonyl)phenyl)-3-Methylpyridin-1-iuM hydroxide(1083057-13-9)

Safety Data

• Hazardous Substances Data: 1083057-13-9(Hazardous Substances Data)

Usage

Chemical structure

2-(3-(tert-butoxycarbonyl)phenyl)-3-Methylpyridin-1-ium hydroxide is a pyridine derivative with a substituted phenyl group and a tert-butoxycarbonyl functional group.

Usage

It is primarily used as a building block in organic synthesis and as a reagent in chemical reactions, particularly in the production of pharmaceuticals and agrochemicals.

Applications

It has applications in drug discovery and development, as well as in the study of biological mechanisms and pathways.

Importance

It is an important and versatile compound in the field of organic chemistry.

Upstream product

• 3430-17-9 2-bromo-3-picoline 
• 85-44-9 phthalic anhydride 
• 1083057-12-8 tert-butyl 3-(3-methylpyridin-2-yl)benzoate 
• 124-43-6 urea hydrogen peroxide adduct 
• 220210-56-0 3-(tert-butoxycarbonyl)phenylboronic acid 

Downstream Products

• 1083057-14-0 tert-butyl 3-(6-amino-3-methylpyridin-2-yl)benzoate 
• 1160221-26-0 Lumacaftor hydrochloride 
• 936727-05-8 Lumacaftor 
• 1160221-25-9 tert-butyl 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzoate 

Relevant articles and documents

METHODS OF TREATMENT FOR CYSTIC FIBROSIS

This application describes methods of treating cystic fibrosis or a CFTR mediated disease comprising administering Compound I or a pharmaceutically acceptable salt thereof. (I) The application also describes pharmaceutical compositions comprising Compound I or a pharmaceutically acceptable salt thereof and optionally comprising one or more additional CFTR modulating agents.

Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809

The 1,2,3-triazole has been successfully utilized as an amide bioisostere in multiple therapeutic contexts. Based on this precedent, triazole analogues derived from VX-809 and VX-770, prominent amide-containing modulators of the cystic fibrosis transmembrane conductance regulator (CFTR), were synthesized and evaluated for CFTR modulation. Triazole 11, derived from VX-809, displayed markedly reduced efficacy in F508del-CFTR correction in cellular TECC assays in comparison to VX-809. Surprisingly, triazole analogues derived from potentiator VX-770 displayed no potentiation of F508del, G551D, or WT-CFTR in cellular Ussing chamber assays. However, patch clamp analysis revealed that triazole 60 potentiates WT-CFTR similarly to VX-770. The efficacy of 60 in the cell-free patch clamp experiment suggests that the loss of activity in the cellular assay could be due to the inability of VX-770 triazole derivatives to reach the CFTR binding site. Moreover, in addition to the negative impact on biological activity, triazoles in both structural classes displayed decreased metabolic stability in human microsomes relative to the analogous amides. In contrast to the many studies that demonstrate the advantages of using the 1,2,3-triazole, these findings highlight the negative impacts that can arise from replacement of the amide with the triazole and suggest that caution is warranted when considering use of the 1,2,3-triazole as an amide bioisostere.

PHARMACEUTICAL COMPOSITIONS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID AND ADMINISTRATION THEREOF

A pharmaceutical composition comprising Compound 1,(3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering an oral pharmaceutical formulation of Compound 1 to the patient.