1083175-01-2

Upstream product

• 129241-89-0 tert-butyl (2S)-2-{bis[(tert-butoxy)carbonyl]amino}-5-oxopentanoate 
• 160256-75-7 N,N''-di-Z-diethylenetriamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 24277-39-2 N-tert-butoxycarbonyl glutamic acid tert-butyl ester 

Downstream Products

• 1083175-02-3 (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-{bis[(tert-butoxy)carbonyl]amino}pentanoic acid 
• 1083175-04-5 (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-{[(tert-butoxy)carbonyl]amino} pentanoic acid 
• 1393477-64-9 tert-butyl (2S)-5-[bis(2-{[(benzyloxy)carbonyl]amino}ethyl)amino]-2-aminopentanoic acid 

Relevant academic research and scientific papers

BORON CONTAINING POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTICS USES THEREOF

Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and theft methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent

POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF

Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.