1083200-79-6

Basic information

• Product Name: 1,7-Bis(4-hydroxyphenyl)hept-1-en-3-one
• Synonyms: 1,7-Bis(4-hydroxyphenyl)hept-1-en-3-one
• CAS NO: 1083200-79-6
• Molecular Formula: C19H20O3
• Molecular Weight: 296.3603
• Mol File: 1083200-79-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,7-Bis(4-hydroxyphenyl)hept-1-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,7-Bis(4-hydroxyphenyl)hept-1-en-3-one(1083200-79-6)
• EPA Substance Registry System: 1,7-Bis(4-hydroxyphenyl)hept-1-en-3-one(1083200-79-6)

Safety Data

• Hazardous Substances Data: 1083200-79-6(Hazardous Substances Data)

Usage

Uses

Due to the lack of extensive documentation on the uses of 1,7-Bis(4-hydroxyphenyl)hept-1-en-3-one, the following potential applications are based on the properties of similar chemical compounds:
Used in Pharmaceutical Industry:
1,7-Bis(4-hydroxyphenyl)hept-1-en-3-one may be used as a pharmaceutical compound for its potential antioxidant and anticancer activities. Similar compounds have been studied for their ability to neutralize free radicals and inhibit the growth of cancer cells.
Used in Cosmetic Industry:
Given its phenolic nature, 1,7-Bis(4-hydroxyphenyl)hept-1-en-3-one could be utilized in cosmetic products for its potential antioxidant properties, which may help protect the skin from oxidative stress and premature aging.
Used in Food Industry:
As an antioxidant, 1,7-Bis(4-hydroxyphenyl)hept-1-en-3-one might be employed in the food industry to extend the shelf life of products by preventing oxidation and spoilage.

Upstream product

• 6515-21-5 4-methoxymethoxy-benzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 
• 84184-57-6 (E)-3-[4-(methoxymethoxy)phenyl]acrylaldehyde 
• 84184-56-5 (E)-3-[4-(methoxymethoxy)phenyl]prop-2-en-1-ol 
• 7400-08-0 p-Coumaric Acid 

Downstream Products

• 130233-83-9 1,7-bis(4'-hydroxyphenyl)-3-heptanone 

Relevant articles and documents

Synthesis of natural and non-natural curcuminoids and their neuroprotective activity against glutamate-induced oxidative stress in HT-22 cells

A strategy for the synthesis of natural and non-natural 5-deoxy-6,7-dihydrocurcuminoids (diarylheptanoids) was developed for the preparation of 14 compounds with varying aromatic substituent patterns and a different functionality in the aliphatic seven-carbon chain. The in vitro protective activity against glutamate-induced neuronal cell death was examined in the murine hippocampal cell line HT-22 to find structural motifs responsible for neuroprotective effects in vitro. Among the tested compounds the ferulic acid-like unit, present in the structures of (E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-1-en-3-one (5) and (E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hept-1-en-3-one (7), appeared to be an important feature for protection against glutamate-induced neurotoxicity. Both compounds demonstrated significant neuroprotective activity in a concentration range between 1 and 25 ～M without showing toxic effects in a cytotoxicity assay with HT-22 cells. Furthermore, (E)-1,7-bis(3,4-dihydroxyphenyl)hept-1-en-3-one (9), exhibiting a caffeic acid-like structural motif, displayed a neuroprotective activity at a nontoxic concentration of 25 ～M. In contrast, (1E,6E)-1,7-bis(3,4-dihydroxyphenyl)hepta-1,6-diene-3,5-dione (4, di-O-demethylcurcumin) showed mainly cytotoxic effects. A corresponding single-ring analogue that contains the ferulic acid-like unit as an enone was not active.