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1083326-17-3

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1083326-17-3 Usage

General Description

N-(5-bromo-2-chloropyridin-3-yl)benzenesulfonamide is a chemical compound with the formula C11H8BrClN2O2S. It is an aromatic amine compound with a sulfonamide functional group, containing a five-membered heterocyclic ring with bromine and chlorine substituents. N-(5-broMo-2-chloropyridin-3-yl)benzenesulfonaMide is commonly used in pharmaceutical and agrochemical research, as well as in the production of other organic compounds. It has been shown to exhibit potential biological and pharmacological activities, including antiviral, antibacterial, and antifungal properties. Overall, N-(5-bromo-2-chloropyridin-3-yl)benzenesulfonamide is of interest to researchers in various fields due to its diverse applications and potential medicinal properties.

Check Digit Verification of cas no

The CAS Registry Mumber 1083326-17-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,8,3,3,2 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1083326-17:
(9*1)+(8*0)+(7*8)+(6*3)+(5*3)+(4*2)+(3*6)+(2*1)+(1*7)=133
133 % 10 = 3
So 1083326-17-3 is a valid CAS Registry Number.

1083326-17-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(5-Bromo-2-chloropyridin-3-yl)benzenesulfonamide

1.2 Other means of identification

Product number -
Other names N-(5-bromo-2-chloro-3-pyridinyl)benzenesulfonamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1083326-17-3 SDS

1083326-17-3Relevant articles and documents

Bioisosteric replacements of the indole moiety for the development of a potent and selective PI3Kδ inhibitor: Design, synthesis and biological evaluation

Chen, Yi,Chen, Zhenxia,Deng, Mingli,Hong, Hui,Jia, Yu,Li, Qingquan,Li, Zhipeng,Ling, Yun,Liu, Xiaofeng,Lu, Mingzhu,Wu, Tianze,Xu, Chenyue,Yang, Chengbin,Yang, Yongtai,Zhou, Yaming

supporting information, (2021/07/10)

Based on indole scaffold, a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor, namely FD223, was developed by the bioisosteric replacement drug discovery approach and studied for the treatment of acute myeloid leukemia (AML). In vitro

Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity

Chen, Yi,Deng, Mingli,Jia, Yu,Ling, Yun,Liu, Xiaofeng,Lu, Mingzhu,Tian, Chengze,Wu, Tianze,Yang, Chengbin,Yang, Yongtai,Zhou, Yaming

supporting information, (2021/07/28)

Cinnoline is a potential pharmacophore which has rarely been reported for uses as PI3K inhibitors. In this study, a series of cinnoline derivatives were developed as PI3K inhibitors and evaluated for enzymatic and cellular activities. Most compounds displ

Discovery of 6′-chloro-N-methyl-5’-(phenylsulfonamido)-[3,3′-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium

Liang, Xiaofei,Jiang, Zongru,Huang, Zhenghui,Li, Feng,Chen, Cheng,Hu, Chen,Wang, Wenliang,Hu, Zhenquan,Liu, Qingwang,Wang, Beilei,Wang, Li,Qi, Ziping,Liu, Jing,Jiang, Lubin,Liu, Qingsong

, (2020/02/06)

Starting from a bipyridine-sulfonamide scaffold, medicinal chemistry optimization leads to the discovery of a novel Plasmodium falciparum PI4K kinase (PfPI4K) inhibitor compound 15g (CHMFL-PI4K-127, IC50: 0.9 nM), which exhibits potent activity against 3D7 Plasmodium falciparum (P. falciparum) (EC50: 25.1 nM). CHMFL-PI4K-127 displays high selectivity against PfPI4K over human lipid and protein kinase. In addition, it exhibits EC50 values of 23–47 nM against a panel of the drug-resistant strains of P. falciparum. In vivo, the inhibitor demonstrates the favorable pharmacokinetic properties in both rats and mice. Furthermore, oral administration of CHMFL-PI4K-127 exhibits the antimalaria efficacy in both blood stage (80 mg/kg) and liver stage (1 mg/kg) of Plasmodium in infected rodent model. The results suggest that CHMFL-PI4K-127 might be a new potential drug candidate for malaria.

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