108375-63-9

Basic information

• Product Name: 1-Methyl-5-(4-methylphenylsulfonyl)-4-nitro-1H-imidazole
• Synonyms: 1-Methyl-5-(4-methylphenylsulfonyl)-4-nitro-1H-imidazole;1-Methyl-5-(4-methylphenylsulfonyl)-4-nitro-1H-
• CAS NO: 108375-63-9
• Molecular Formula: C₁₁H₁₁N₃O₄S
• Molecular Weight: 281.28774
• Mol File: 108375-63-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 558.3°C at 760 mmHg
• Flash Point: 291.4°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 6.34E-12mmHg at 25°C
• Refractive Index: 1.651
• CAS DataBase Reference: 1-Methyl-5-(4-methylphenylsulfonyl)-4-nitro-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-5-(4-methylphenylsulfonyl)-4-nitro-1H-imidazole(108375-63-9)
• EPA Substance Registry System: 1-Methyl-5-(4-methylphenylsulfonyl)-4-nitro-1H-imidazole(108375-63-9)

Safety Data

• Hazardous Substances Data: 108375-63-9(Hazardous Substances Data)

Usage

Explanation

Different sources of media describe the Explanation of 108375-63-9 differently. You can refer to the following data:
1. The compound consists of 12 carbon atoms, 12 hydrogen atoms, 4 nitrogen atoms, 4 oxygen atoms, and 1 sulfur atom in a single molecule.
2. Nitroimidazole derivative
2. It is a chemical compound derived from the nitroimidazole structure, which is characterized by an imidazole ring containing a nitro group (-NO2).
3. Pharmaceutical intermediate
3. The compound serves as an intermediate in the synthesis of various pharmaceuticals and other organic compounds, meaning it is used as a starting material or reactant in the production of these compounds.
4. Medicinal chemistry applications
4. 1-Methyl-5-(4-methylphenylsulfonyl)-4-nitro-1H-imidazole has potential applications in the field of medicinal chemistry, particularly in the development of new drugs for the treatment of various diseases.
5. Purity and concentration-dependent properties
5. The specific properties and potential uses of the compound may vary depending on its purity, concentration, and specific synthesis method.
6. Further research and testing required
6. To fully understand the potential applications and safety profile of 1-Methyl-5-(4-methylphenylsulfonyl)-4-nitro-1H-imidazole, additional research and testing are necessary.

InChI:InChI=1/C11H11N3O4S/c1-8-3-5-9(6-4-8)19(17,18)11-10(14(15)16)12-7-13(11)2/h3-7H,1-2H3

Upstream product

• 933-87-9 1-methyl-5-bromo-4-nitro-1H-imidazole 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 106-45-6 para-thiocresol 
• 18383-80-7 1-methyl-5-(4'-methylphenyl)thio-4-nitroimidazole 

Relevant articles and documents

Synthesis and In-vitro antibacterial activity of 5-substituted 1-methyl-4-nitro-1H-imidazoles

A series of 5-substituted 1-methyl-4-nitro-1H-imidazole derivatives were synthesized and evaluated for in-vitro antibacterial activity against a panel of microorganisms including Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Esherichia coli, Klebsiella pneumonia, Entrobacter aerogenes, and Helicobacter pylori using conventional agar dilution method. Among the test compounds, 1-methyl-4-nitro-5-(phenylsulfonyl)-1H-imidazole was the most potent against Gram-positive bacteria, with a MIC value of ≤8 μg/mL. All compounds showed no significant activity against Gram-negative bacteria at concentrations ≤64 μg/mL The MIC values against 15 clinical isolates of H. pylori indicated that compounds 10 and 11 were the most active compounds in this series in terms of inhibiting the growth of H. pylori (MIC = 2 μg/mL). It was also demonstrated that their corresponding activities were four times larger than that of metronidazole.