1084-62-4

Usage

Uses

Used in Fragrance Industry:
1-(2-Hydroxyphenyl)-3-(piperidino)-2-propene-1-one is used as a fragrance ingredient for its aromatic properties in the manufacturing of perfumes, soaps, and other personal care products. Its unique scent contributes to the overall appeal of these products, enhancing their marketability and consumer experience.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 1-(2-Hydroxyphenyl)-3-(piperidino)-2-propene-1-one is used as a precursor in the synthesis of various pharmaceuticals. Its chemical structure allows for the development of new drugs with potential therapeutic benefits.
Used in Agrochemicals:
1-(2-Hydroxyphenyl)-3-(piperidino)-2-propene-1-one also serves as a precursor in the synthesis of agrochemicals, specifically in the development of insecticides and pest control products. Its insecticidal and acaricidal properties make it a valuable component in the formulation of these products, helping to protect crops and maintain agricultural productivity.
Used in Insecticides and Pest Control:
1-(2-Hydroxyphenyl)-3-(piperidino)-2-propene-1-one is used as an active ingredient in insecticides and pest control products due to its demonstrated effectiveness against various insects and mites. Its incorporation into these products helps to control and manage pest populations, reducing their impact on crops and the environment.
It is crucial to handle and use 1-(2-Hydroxyphenyl)-3-(piperidino)-2-propene-1-one with care, as it may pose potential health hazards and toxicity. Proper safety measures and guidelines should be followed to minimize risks associated with its use.

Upstream product

• 110-89-4 piperidine 
• 491-38-3 1-benzopyran-4(4H)-one 
• 49619-82-1 3-bromo-4H-chromen-4-one 
• 122775-34-2 3-iodo-chromen-4-one 
• 17422-74-1 3-Formylchromone 
• 106129-86-6 1-(2-hydroxyphenyl)-3-dimethylaminoprop-2-enone 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 59507-94-7 3-amino-4H-chromen-4-one 

Relevant academic research and scientific papers

Synthesis of 1-(2-hydroxy-phenyl)-3-piperidin-1-yl-propenone by ultrasonic irradiation

Different 1-(2-hydroxy-phenyl)-3-piperidin-1-yl-propenones have been synthesized by ultrasonic activation from differently substituted 3-formyl chromones and piperidine. Copyright Taylor & Francis Group, LLC.

Analogues of Dehydroacetic Acid as Selective and Potent Agonists of an Ectopic Odorant Receptor through a Combination of Hydrophilic and Hydrophobic Interactions

Identification of potent agonists of odorant receptors (ORs), a major class of G protein-coupled receptors, remains challenging due to complex receptor–ligand interactions. ORs are present in both olfactory and non-chemosensory tissues, indicating roles beyond odor detection that may include modulating physiological functions in non-olfactory tissues. Selective and potent agonists specific for particular ORs can be used to investigate physiological functions of ORs in non-chemosensory tissues. In this study, we designed and synthesized novel synthetic dehydroacetic acid analogues as agonists of odorant receptor 895 (Olfr895) expressed in bladder. Among the synthesized analogues, (E)-3-((E)-1-hydroxy-3-(piperidin-1-yl)allylidene)-6-methyl-2H-pyran-2,4(3H)-dione (10) exhibited extremely high agonistic activity for Olfr895 in Dual-Glo luciferase reporter (EC50=9 nm), Ca2+ imaging, and chemotactic migration assays. Molecular docking and site-directed mutagenesis studies suggested that a combination of hydrophilic and hydrophobic interactions is central to the selective and specific binding of 10 to Olfr895. The design of agonists armed with both hydrophilic and hydrophobic portions could therefore lead to highly potent and selective ligands for ectopic ORs.

Reaction of 3-iodochromone with nucleophiles 3. Formation of 2-aminomethylene-3(2h)-benzofuranones by the reaction with secondary amines

3-Iodochromone (4a) easily reacted with secondary amines in the presence of potassium carbonate to give 2-aminomethylene-3(2H)-benzofuranones in good yields. Under similar conditions without potassium carbonate, 4a was reacted with piperidine to give the