108444-16-2

Upstream product

• 108444-19-5 3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-isoindol-1-one 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 2142-04-3 2-(4-methoxyphenyl)isoindoline-1,3-dione 
• 7472-54-0 N-(p-methoxyphenyl)benzamide 
• 140-88-5 ethyl acrylate 
• 609-67-6 2-Iodobenzoyl chloride 
• 88-67-5 2-Iodobenzoic acid 
• 36684-49-8 2-iodo-N-(4-methoxyphenyl)benzamide 

Downstream Products

• 88460-55-3 2,3-Dihydro-3-oxo-2-(p-methoxyphenyl)-1H-isoindole-1-acetic Acid 
• 132868-77-0 2,3-Dihydro-3-oxo-2-phenyl-1H-isoindole-1-acetyl Chloride 

Relevant academic research and scientific papers

Non-coordinating-Anion-Directed Reversal of Activation Site: Selective C?H Bond Activation of N-Aryl Rings

An Rh-catalyzed selective C?H bond activation of diaryl-substituted anilides is described. In an attempt to achieve C?H activation of C-aryl rings, we unexpectedly obtained an N-aryl ring product under non-coordinating anion conditions, whereas the C-aryl

Palladium mediated synthesis of isoindolinones and isoquinolinones

The palladium-catalyzed reactions of 2-iodo-N-substituted benzamides 5-10 with acrylic esters 11-14 led to N-substituted-3-alkylisoindolinone esters 15-22 in good yields. The esters of isoindolinones 15-22 underwent hydrolysis reactions yielding the N-aryl-1,2,3,4-tetrahydro-1-oxoisoquinoline-3-carboxylic acid 26-31 in good yields.

A Novel Synthesis of N-Substituted-3-carboethoxymethylphthalimidines

A novel synthesis of N-substituted-3-carboethoxymethylphthalimidines 5 is described from secondary benzamides.The benzamides 1 on lithiation with n-butyllithium followed by treatment with dimethylformamide furnish 3-hydroxyphthalimidines 2 in 74-84percent