108471-85-8

Upstream product

• 108471-37-0 5-Benzyl-2-dimethylamino-4-phenyl-[1,3]oxazin-6-one 
• 108510-36-7 ((Z)-2-Dimethylcarbamoyl-1,3-diphenyl-propenyl)-carbamic acid methyl ester 
• 18871-71-1 N,N-dimethyl 3-oxo-3-phenyl-propanamide 
• 100-52-7 benzaldehyde 
• 100-39-0 benzyl bromide 

Relevant academic research and scientific papers

REDUCTION METHOD AND REDUCTION PRODUCT OF ALKENYL ACTIVE METHYLENE COMPOUND

Disclosed are a reduction method and reduction product of an alkenyl active methylene compound. The reduction reaction comprises the following steps: taking an alkenyl active methylene compound as a substrate, a metal hydride as a reducing agent, and a palladium compound as a catalyst, performing a reduction reaction to obtain a reduction product, and then reducing the alkenyl active methylene compound. The reduction system is a simple method for reducing the alkenyl active methylene compound, and the used hydride and palladium compound catalyst are both reagents that could easily be obtained in a laboratory. Compared with conventional hydrogen hydrogenation methods and reduction methods of reducing agents, the method is easier to operate, higher in safety, mild in conditions, and high in reaction yield, a reaction in a one-pot two-step manner can be achieved, and high atom economy and step economy can be obtained.

Manganese-Catalyzed anti-Selective Asymmetric Hydrogenation of α-Substituted β-Ketoamides

A Mn-catalyzed diastereo- and enantioselective hydrogenation of α-substituted β-ketoamides has been realized for the first time under dynamic kinetic resolution conditions. anti-α-Substituted β-hydroxy amides, which are useful building blocks for the synthesis of bioactive molecules and chiral drugs, were prepared in high yields with excellent selectivity (up to >99 percent dr and >99 percent ee) and unprecedentedly high activity (TON up to 10000). The origin of the excellent stereoselectivity was clarified by DFT calculations.

The Employment of Sodium Hydride as a Michael Donor in Palladium-catalyzed Reductions of α, β-Unsaturated Carbonyl Compounds

Sodium hydride was employed as a Michael donor under the catalysis of PdCl2 for 1,4-conjugate reductions of α, β-unsaturated carbonyl compounds, which features operational simplicity, mild conditions and high atom-economy. The merits of NaH as a reductant were demonstrated by the one-pot or cascade reactions for the syntheses of complex molecules. (Figure presented.).

Reduction method and reduction product of alkenyl active methylene compound

The invention discloses a reduction method and reduction product of an alkenyl active methylene compound. The reduction reaction comprises the following steps: taking the alkenyl active methylene compound as a substrate, a metal hydride as a reducing agent, a palladium compound as a catalyst, performing a reduction reaction to obtain the reduction product, and then reducing the alkenyl active methylene compound. The reduction system of the invention is a simple method for reducing the alkenyl active methylene compound, used hydride and a palladium compound catalyst are all easily obtained reagents in the laboratory, compared with the conventional hydrogen hydrogenation method and the reduction method of the reducing agent, the method is easier to operate, higher in safety, mild in conditions and high in reaction yield, and can be reacted in a one-pot two-step manner, thereby having very high atom economy and step economy.

The Vilsmeier-Haack Reaction of Isoxazolin-5-ones. Synthesis and Reactivity of 2-(Dialkylamino)-1,3-oxazin-6-ones

The Vilsmeier-Haack reaction on isoxazolin-5-ones gives 2-(dialkylamino)-1,3-oxazin-6-ones, and a reaction path is proposed depending on substitution pattern of the isoxazolin-5-ones studied.A thermal equilibrium between the oxazinones, imino ketenes, and vinyl isocyanates is hypothesized to explain most of the chemical reactivity of the 2-(dialkylamino)-1,3-oxazin-6-ones.