108507-42-2

Basic information

• Product Name: (R)OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID
• Synonyms: (R)OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID;1H-Indole-2-carboxylicacid,octahydro-,(2R,3aR,7aR)-(9CI);(2R)-Octahydroindole-2-carboxylic acid;(2R)-octahydro-1H-indole-2-carboxylic acid
• CAS NO: 108507-42-2
• Molecular Formula: C₉H₁₅NO₂
• Molecular Weight: 169.22
• Product Categories: PYRROLE
• Mol File: 108507-42-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 318.6°Cat760mmHg
• Flash Point: 146.5°C
• Appearance: /
• Density: 1.135g/cm³
• Vapor Pressure: 7.54E-05mmHg at 25°C
• Refractive Index: 1.507
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.47±0.20(Predicted)
• CAS DataBase Reference: (R)OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R)OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID(108507-42-2)
• EPA Substance Registry System: (R)OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID(108507-42-2)

Safety Data

• Hazardous Substances Data: 108507-42-2(Hazardous Substances Data)

Usage

General Description

(R)OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID is a chemical compound with the molecular formula C10H17NO2. It is a derivative of indole, a widely occurring heterocyclic organic compound. This chemical is a carboxylic acid, meaning it contains a carboxyl group (COOH). It is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active compounds, such as drugs and natural products. Its structure and properties make it a valuable intermediate in the production of a wide range of chemical compounds.

InChI:InChI=1/C9H15NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h6-8,10H,1-5H2,(H,11,12)/t6-,7-,8-/m1/s1

Upstream product

• 87623-95-8 (2R,3aS,7aR)-1-Acetyl-octahydro-indole-2-carbonitrile 
• 59224-99-6 trans-3,4,4a,5,6,7,8,8a-Octahydro-2(1H)-quinolinone 
• 87623-95-8 (2S,3aR,7aR)-1-Acetyl-octahydro-indole-2-carbonitrile 
• 1193-68-6 cis-octahydroindole 
• 98167-06-7 (R)-(-)-2,3-Dihydro-1H-Indole-2-Carboxylic Acid 
• 80828-31-5 (2α,3aβ,7aβ)-1-benzoyloctahydro-1H-indole-2-carboxylic acid 
• 79799-08-9 (2S,3aS,7aS)-Octahydro-indole-2-carboxylic acid ethyl ester 
• 80828-13-3 (+/-)-(2S,3aS,7aS)-octahydroindole-2-carboxylic acid 
• 3770-50-1 2-carbethoxyindole 
• 108507-45-5 (2R,3aR,7aR)-1-Benzoyl-octahydro-indole-2-carboxylic acid 
• 87623-93-6 (3aR,7aR)-1-(Octahydro-indol-1-yl)-ethanone 
• 4169-27-1 cis-3,4,4a,5,6,7,8,8a-Octahydro-2(1H)-quinolinone 
• 120-72-9 indole 
• 16851-56-2 indolin-2-yl carboxylic acid 

Downstream Products

• 80828-12-2 (2R,3aR,7aR)-1-(3-Acetylsulfanyl-propionyl)-octahydro-indole-2-carboxylic acid 
• 80876-00-2 (2α,3aβ,7aβ)-octahydro-1H-indole-2-carboxylic acid 1,1-dimethylethyl ester 
• 82717-91-7 (+/-)-benzyl (2S,3aS,7aS)-octahydroindole-2-carboxylate p-toluenesulfonic acid salt 
• 80876-00-2 (2α,3aβ,7aβ)-octahydro-1H-indole-2-carboxylic acid tert-butyl ester 
• 80875-98-5 (2S,3aS,7aS)-perhydroindole-2-carboxylic acid 
• 80875-99-6 (2S,3aS,7aS)-1-Benzoyl-octahydro-indole-2-carboxylic acid 
• 108395-27-3 (6aα,10aα,11aα)-decahydro-1H,5H-<1,4>thiazepino<4,3-a>indole-1,5-dione 
• 108395-26-2 (2S,3aS,7aS)-1-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-octahydro-indole-2-carboxylic acid 
• 108449-52-1 (2R,3aR,7aR)-1-[(S)-2-((R)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-octahydro-indole-2-carboxylic acid; hydrochloride 
• 80828-32-6 Indolapril hydrochloride 
• 108507-42-2 (2R,3aR,7aR)-Octahydro-indole-2-carboxylic acid 
• 108507-43-3 (2R,3aR,7aR)-Octahydro-indole-2-carboxylic acid tert-butyl ester 
• 80828-20-2 (2α, 3aβ, 7aβ)-Octahydro-1-(3-mercaptopropanoyl)-1H-indole-2-carboxylic Acid 
• 80828-20-2 (2R,3aR,7aR)-1-(3-Mercapto-propionyl)-octahydro-indole-2-carboxylic acid 

Relevant articles and documents

Efficient access to N-protected derivatives of (R,R,R)- and (S,S,S)-octahydroindole-2-carboxylic acid by HPLC resolution

The preparation of the proline analogue (2S,3aS,7aS)-octahydroindole-2-carboxylic acid (Oic) and its enantiomer, (2R,3aR,7aR)-Oic, is described. A racemic precursor has been synthesized in good yield and subjected to HPLC resolution on a chiral column. The high efficiency of both the synthetic and chromatographic procedures has allowed the isolation of multigram quantities of each amino acid in enantiomerically pure form and suitably protected for use in peptide synthesis.

Synthesis and structure-activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids

-

COUPLING OF β-ACETAMIDO RADICALS WITH α-CHLORO ACRYLONITRILE - A NEW ACCESS TO DISUBSTITUTED PROLINE DERIVATIVES

β-Acetamido radicals are prepared by reduction of organomercurials and coupled with α-chloro-acrylonitrile.The coupling products are further converted to proline derivatives.