80876-00-2

Basic information

• Product Name: 2-AMINO-3-BROMOBENZOPHENONE
• Synonyms: 2-AMINO-3-BROMOBENZOPHENONE;2-AMINO-3-BROMOACETOPHENONE;1-(2-Amino-3-bromophenyl)ethanone
• CAS NO: 80876-00-2
• Molecular Formula: C13H23NO2
• Molecular Weight: 225.331
• Mol File: 80876-00-2.mol
• Article Data: 4

Chemical Properties

• Flash Point: 137℃
• CAS DataBase Reference: 2-AMINO-3-BROMOBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-BROMOBENZOPHENONE(80876-00-2)
• EPA Substance Registry System: 2-AMINO-3-BROMOBENZOPHENONE(80876-00-2)

Safety Data

• Hazardous Substances Data: 80876-00-2(Hazardous Substances Data)

Usage

Chemical structure

benzophenone derivative with a bromine atom at the 3-position and an amino group at the 2-position of the benzene ring

Primary use

building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds

Biological activities

studied for potential biological activities

Reactant

used in the production of various organic substances

Hazards

should be handled with caution as it can pose hazards to human health and the environment if not properly managed

Upstream product

• 80828-13-3 (+/-)-(2S,3aS,7aS)-octahydroindole-2-carboxylic acid 
• 75-65-0 tert-butyl alcohol 
• 79799-08-9 (2S,3aS,7aS)-Octahydro-indole-2-carboxylic acid ethyl ester 
• 3770-50-1 2-carbethoxyindole 
• 115-11-7 isobutene 
• 107045-53-4 (2S,3aS,7aS)-1-(benzyloxycarbonyl)octahydro-1H-indole-2-carboxylic acid 
• 79815-20-6 (S)-indoline-2-carboxylic acid 
• 80875-98-5 (2S,3aS,7aS)-perhydroindole-2-carboxylic acid 
• 79854-42-5 Ethyl (S)-indoline-2-carboxylate hydrochloride 
• 82864-25-3 ethyl (2S,3aS,7aS)-octahydro-1H-indole-2-carboxylate hydrochloride 
• 80876-00-2 (2α,3aβ,7aβ)-octahydro-1H-indole-2-carboxylic acid 1,1-dimethylethyl ester 

Downstream Products

• 120008-88-0 (2S,3aS,7aS)-1-{(S)-2-[(S)-5-(1-Benzyloxycarbonyl-piperidin-4-yl)-1-ethoxycarbonyl-pentylamino]-propionyl}-octahydro-indole-2-carboxylic acid tert-butyl ester 
• 120008-88-0 (2S,3aS,7aS)-1-{(S)-2-[(R)-5-(1-Benzyloxycarbonyl-piperidin-4-yl)-1-ethoxycarbonyl-pentylamino]-propionyl}-octahydro-indole-2-carboxylic acid tert-butyl ester 
• 120008-86-8 1--L-alanyl>-(2α,3aβ,7aβ)-octahydro-1H-indole-2-carboxylic acid tert-butyl ester 
• 120008-86-8 (2S,3aS,7aS)-1-{(S)-2-[(R)-6-(1-Benzyloxycarbonyl-piperidin-4-yl)-1-ethoxycarbonyl-hexylamino]-propionyl}-octahydro-indole-2-carboxylic acid tert-butyl ester 
• 80828-33-7 tert-butyl (2S,3aS,7aS)-1-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl)octahydro-1H-indole-2-carboxylate 
• 145513-37-7 (2S,3aS,7aS)-1--(R)-alanyl>-2-carboxyperhydroindole 
• 145513-54-8 1-<(2S) 2-<((1S) 1-carbethoxybutyl) amino> 1-oxo propyl> (2S, 3aS, 7aS) perhydroindole 2-carboxylic acid 
• 80828-33-7 (2S,3aS,7aS)-1-[(S)-2-((R)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-octahydro-indole-2-carboxylic acid tert-butyl ester 
• 615583-05-6 C₂₇H₄₀N₂O₅ 
• 615583-15-8 C₄₀H₆₁N₅O₇ 
• 615583-16-9 C₃₂H₅₅N₅O₅ 
• 945255-39-0 C₃₇H₅₇N₇O₆ 
• 945255-42-5 C₃₈H₅₈N₆O₆ 
• 945255-43-6 C₃₈H₅₈N₆O₆ 

Relevant articles and documents

Continuous Flow Synthesis of ACE Inhibitors From N-Substituted l-Alanine Derivatives

A strategy for the continuous flow synthesis of angiotensin converting enzyme (ACE) inhibitors is described. An optimization effort guided by in situ IR analysis resulted in a general amide coupling approach facilitated by N-carboxyanhydride (NCA) activation that was further characterized by reaction kinetics analysis in batch. The three-step continuous process was demonstrated by synthesizing 8 different ACE inhibitors in up to 88 % yield with throughputs in the range of ≈0.5 g h?1, all while avoiding both isolation of reactive intermediates and process intensive reaction conditions. The process was further developed by preparing enalapril, a World Health Organization (WHO) essential medicine, in an industrially relevant flow platform that scaled throughput to ≈1 g h?1.

Synthesis and structure-activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids

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